Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait, Kuwait.
Ann Hematol. 2010 Feb;89(2):179-84. doi: 10.1007/s00277-009-0801-z. Epub 2009 Aug 28.
There is a wide variation in the prevalence of various subtypes of non-Hodgkin's lymphoma worldwide. The aim of this study was to determine the relative frequency of different subtypes of non-Hodgkin's lymphoma in Kuwait based on the Revised European-American Lymphoma (REAL) classification. From 1998 to 2006, 738 subjects were included that were registered with non-Hodgkin's lymphoma in the population-based cancer registry at the Kuwait Cancer Control Center. Expert pathologists reviewed histological slides from all subjects. We performed detailed immunohistochemical studies and classified subjects based on the REAL classification. The prevalence of different types of non-Hodgkin's lymphoma was determined based on age, sex, site of disease, and ethnicity. Ethnicity groups comprised Kuwaiti Arabs, non Kuwaiti Arabs, Asians, and others. The prevalence of B- and T-cell lymphomas was 81.8% and 14.2%, respectively. The most common age group was 41-60 years old. The three most common subtypes in Kuwaiti Arabs were diffuse large B-cell lymphoma (46.5%), follicular lymphoma (15.5%), and mycosis fungoides (9.3%). In non-Kuwaiti Arabs, the most common subtypes were diffuse large B-cell lymphoma (48%), B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia (15.8%), and follicular lymphoma (12.7%). Overall, non-Kuwaiti Arabs exhibited the highest prevalence (59%), and 54% of all cases had extranodal presentation. Compared to the Western world, Kuwait had a lower prevalence of follicular lymphoma, a higher prevalence of diffuse large B-cell lymphoma and extranodal presentation, and a high frequency of mycosis fungoides. Compared to other parts of Asia, Kuwait had a lower frequency of peripheral T-cell lymphomas.
全球范围内，各种非霍奇金淋巴瘤亚型的患病率存在广泛差异。本研究旨在根据修订后的欧洲-美洲淋巴瘤（REAL）分类，确定科威特非霍奇金淋巴瘤的不同亚型的相对频率。1998 年至 2006 年期间，共有 738 名在科威特癌症控制中心的基于人群的癌症登记处登记患有非霍奇金淋巴瘤的患者被纳入研究。专家病理学家对所有患者的组织学切片进行了复查。我们进行了详细的免疫组织化学研究，并根据 REAL 分类对患者进行了分类。根据年龄、性别、疾病部位和种族确定了不同类型非霍奇金淋巴瘤的患病率。种族群体包括科威特阿拉伯人、非科威特阿拉伯人、亚洲人和其他人。B 细胞和 T 细胞淋巴瘤的患病率分别为 81.8%和 14.2%。最常见的年龄组为 41-60 岁。在科威特阿拉伯人中，最常见的亚型是弥漫性大 B 细胞淋巴瘤（46.5%）、滤泡性淋巴瘤（15.5%）和蕈样真菌病（9.3%）。在非科威特阿拉伯人中，最常见的亚型是弥漫性大 B 细胞淋巴瘤（48%）、B 细胞小淋巴细胞性淋巴瘤/慢性淋巴细胞性白血病（15.8%）和滤泡性淋巴瘤（12.7%）。总体而言，非科威特阿拉伯人的患病率最高（59%），54%的病例为结外表现。与西方世界相比，科威特滤泡性淋巴瘤的患病率较低，弥漫性大 B 细胞淋巴瘤和结外表现的患病率较高，蕈样真菌病的发生率较高。与亚洲其他地区相比，科威特外周 T 细胞淋巴瘤的频率较低。
