Habeebu M Y, Salako O, Okediji P T, Mabadeje B, Awofeso O M, Ajekigbe A T, Abdulkareem F B
Department of Radiotherapy, Lagos University Teaching Hospital, Idi-Araba, Lagos.
Research & Development, Sebeccly Cancer Care, Yaba, Lagos.
J West Afr Coll Surg. 2017 Jan-Mar;7(1):9-31.
Gastrointestinal malignancies have continued to record higher incidence and therefore pose significant public health burden in terms of morbidity and mortality.
To evaluate the sociodemographic, histologic and clinical distribution of patients with gastrointestinal malignancies diagnosed between July 2009 and March 2016.
Lagos University Teaching Hospital, Idi-Araba, south-west Nigeria.
Using a retrospective study design, all the patients with histologic diagnosis of gastrointestinal malignancies were recruited and their bio-data, clinical, histologic and treatment data were extracted from their hospital records.
Of the 106 cases of gastrointestinal malignancies in this study, the age range was 30-82 years with a mean of 55.9±13 years and a peak age bracket of 50-59 years; the male/female ratio was 1.2:1. The most common sites were colorectum (79.3%), stomach (7.6%), anus (6.6%), liver (4.7%), and pancreas (0.9%). Adenocarcinoma was the most common histologic subtype (89.62%), followed by squamous cell carcinoma (2.83%) and gastrointestinal stromal tumors (1.89%). The most common complaints were abdominal pain (54.7%), constipation (38.7%), palpable abdominal swelling/masses (35.9%), bleeding (33.0%), and weight loss (17.0%). The tumors were treated with chemotherapy, surgery, and radiotherapy, either singly or in combination, in 97.2%, 83.0%, and 30.2% respectively.
In this study, colorectal cancers are still the most prevalent type of gastrointestinal malignancies with a male preponderance, and individuals between 40-59 years are at greater risk. The significant involvement of individuals who constitute the bulk of the workforce and are the most productive labor in the country points at the need to develop strategies aimed at reducing the incidence of gastrointestinal malignancies.
胃肠道恶性肿瘤的发病率持续上升，因此在发病率和死亡率方面造成了重大的公共卫生负担。
评估2009年7月至2016年3月期间诊断为胃肠道恶性肿瘤患者的社会人口统计学、组织学和临床分布情况。
尼日利亚西南部伊迪-阿拉巴的拉各斯大学教学医院。
采用回顾性研究设计，招募所有经组织学诊断为胃肠道恶性肿瘤的患者，并从其医院记录中提取他们的生物数据、临床、组织学和治疗数据。
本研究中的106例胃肠道恶性肿瘤患者，年龄范围为30 - 82岁，平均年龄为55.9±13岁，年龄峰值在50 - 59岁；男女比例为1.2:1。最常见的部位是结肠直肠（79.3%）、胃（7.6%）、肛门（6.6%）、肝脏（4.7%）和胰腺（0.9%）。腺癌是最常见的组织学亚型（89.62%），其次是鳞状细胞癌（2.83%）和胃肠道间质瘤（1.89%）。最常见的症状是腹痛（54.7%）、便秘（38.7%）、可触及的腹部肿胀/肿块（35.9%）、出血（33.0%）和体重减轻（17.0%）。分别有97.2%、83.0%和30.2%的肿瘤采用化疗、手术和放疗单独或联合治疗。
在本研究中，结直肠癌仍然是最常见的胃肠道恶性肿瘤类型，男性居多，40 - 59岁的个体风险更高。构成劳动力主体且是该国最具生产力劳动者的人群大量受累，这表明需要制定旨在降低胃肠道恶性肿瘤发病率的策略。
