Department of Diabetes and Endocrinology, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
J Diabetes Res. 2018 May 23;2018:4504287. doi: 10.1155/2018/4504287. eCollection 2018.
Diabetes incurs heavy burden to patients and the healthcare system. Assessment of disease burden is important in taking necessary precautions and management decisions. We aimed to determine the prevalence of macro- and microvascular complications, their risk factors, and coronary artery disease (CAD) risk factors among patients with type 2 diabetes mellitus (T2DM). A descriptive cross-sectional single-centre study was carried out among 3000 patients with T2DM attending the diabetic clinic at the National Hospital of Sri Lanka from January to July 2016. The study population had 72.7% females and 27.3% males. Mean age and disease duration were 58.3 ± 10.3 and 10.8 ± 7 years, respectively. Prevalence of CAD, stroke, and peripheral vascular disease were 10.6%, 1.1%, and 4.7% while diabetic retinopathy, neuropathy, nephropathy, diabetic foot, and lower extremity amputation (LEA) were 26.1%, 62.6%, 50.8%, 2.6%, and 1.3%, respectively. Prevalence of overweight/obesity, hypertension, dyslipidemia, and smoking were 80%, 77.6%, 76.7%, and 11%, respectively. Increased age, disease duration, and HBA1c were risk factors for microvascular disease and diabetic foot while age was the only risk factor for macrovascular complications. Occurrence of CAD, peripheral neuropathy, diabetic foot, and LEA was significantly higher among males than when compared to females. This study highlights the major burden of chronic complications and high prevalence of CAD risk factors in this population.
糖尿病给患者和医疗系统带来了沉重的负担。评估疾病负担对于采取必要的预防措施和管理决策非常重要。我们旨在确定 2 型糖尿病 (T2DM) 患者的大血管和微血管并发症及其危险因素,以及冠心病 (CAD) 的危险因素。这是一项描述性的横断面单中心研究,于 2016 年 1 月至 7 月在斯里兰卡国家医院的糖尿病诊所对 3000 名 T2DM 患者进行。研究人群中女性占 72.7%,男性占 27.3%。平均年龄和病程分别为 58.3±10.3 岁和 10.8±7 年。CAD、中风和外周血管疾病的患病率分别为 10.6%、1.1%和 4.7%,而糖尿病视网膜病变、神经病变、肾病、糖尿病足和下肢截肢 (LEA) 的患病率分别为 26.1%、62.6%、50.8%、2.6%和 1.3%。超重/肥胖、高血压、血脂异常和吸烟的患病率分别为 80%、77.6%、76.7%和 11%。年龄、病程和 HBA1c 的增加是微血管疾病和糖尿病足的危险因素,而年龄是大血管并发症的唯一危险因素。与女性相比,男性 CAD、周围神经病变、糖尿病足和 LEA 的发生率明显更高。本研究强调了该人群慢性并发症的主要负担和 CAD 危险因素的高患病率。