成人肠道衰老模型。

Adult Intestine Aging Model.

机构信息

Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan.

出版信息

Adv Exp Med Biol. 2018;1076:11-23. doi: 10.1007/978-981-13-0529-0_2.

Abstract

The Drosophila adult has an intestine composed of a series of differentiated cells and tissue stem cells, all of which are similar to the mammalian intestinal cells. The aged adult intestine shows apparent characteristics such as multilayering of absorptive cells, misexpression of cell type-specific genes, and hyperproliferation of stem cells. Recent studies have revealed various gene networks responsible for progression of these aged phenotypes. The molecular mechanism for senescence of the Drosophila adult midgut and its relation with the corresponding mechanism in mammals are overviewed. In addition, a basic method for observing aged phenotypes of the midgut is described.

摘要

果蝇的成年个体的肠道由一系列分化的细胞和组织干细胞组成，所有这些细胞和组织干细胞都类似于哺乳动物的肠道细胞。衰老的成年个体的肠道表现出明显的特征，如吸收细胞的多层化、细胞类型特异性基因的异常表达以及干细胞的过度增殖。最近的研究揭示了各种负责这些衰老表型进展的基因网络。本文综述了果蝇成年中肠衰老的分子机制及其与哺乳动物相应机制的关系。此外，还描述了一种观察中肠衰老表型的基本方法。