Wang Ping, Hou Steven X
The Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA.
J Cell Physiol. 2010 Jan;222(1):33-7. doi: 10.1002/jcp.21928.
The digestive systems in mammals and Drosophila are quite different in terms of their complexity and organization, but their biological functions are similar. The Drosophila midgut is a functional equivalent of the mouse small intestine. Adult intestinal stem cells (ISCs) have been identified in both the mouse small intestine and Drosophila midgut. The anatomy and cell renewal in the Drosophila midgut are similar to those in the mouse small intestine: the intestinal epithelium in both systems is a tube composed of epithelial cells with absorptive and secretory functions; the Notch signaling controls absorptive versus secretory fate decisions in the intestinal epithelium; cell renewal in both systems starts from stem cells in the basal cell layer, and the differentiated cells then move toward the lumen. However, it is clear that the stem cells in the two systems are regulated in different ways. In this review, we will compare cell renewal and stem cell regulation in the two systems.
哺乳动物和果蝇的消化系统在复杂性和组织结构方面有很大差异，但它们的生物学功能相似。果蝇中肠相当于小鼠的小肠。在小鼠小肠和果蝇中肠中均已鉴定出成体肠道干细胞（ISC）。果蝇中肠的解剖结构和细胞更新与小鼠小肠相似：两个系统的肠上皮都是由具有吸收和分泌功能的上皮细胞组成的管状物；Notch信号通路控制肠上皮中吸收性与分泌性命运的决定；两个系统中的细胞更新均始于基底层的干细胞，然后分化细胞向管腔移动。然而，很明显这两个系统中的干细胞受到不同方式的调节。在这篇综述中，我们将比较这两个系统中的细胞更新和干细胞调节。
