Department of Mathematics and Computer Science, University of Richmond, Virginia, 23173, USA.
Bull Math Biol. 2018 Aug;80(8):2242-2271. doi: 10.1007/s11538-018-0459-6. Epub 2018 Jun 27.
The human body's immune response to bacterial challenge, even when successful in controlling the infection, can result in negative consequences for the host, including reduced functionality of associated tissues. We present and analyze a low-dimensional mathematical model of this immune response to pathogen invasion, incorporating the coordinated actions of active immune cells, and both pro- and anti-inflammatory cytokines. The model simulates both the positive (pathogen reduction) and negative (local tissue dysfunction) effects of the immune response and includes the important role of immunologic memory in the process of a return to stasis. This differential equation-based model is sufficiently general to be applicable to a wide range of human tissues and organs.
人体对细菌挑战的免疫反应，即使成功控制了感染，也会对宿主造成负面影响，包括相关组织功能下降。我们提出并分析了一个针对病原体入侵的免疫反应的低维数学模型，该模型纳入了活性免疫细胞以及促炎和抗炎细胞因子的协调作用。该模型模拟了免疫反应的积极（病原体减少）和消极（局部组织功能障碍）影响，并包括免疫记忆在恢复稳定过程中的重要作用。这个基于微分方程的模型足够通用，可以应用于广泛的人体组织和器官。
