Burgdorf W
J Am Acad Dermatol. 1981 Dec;5(6):689-95. doi: 10.1016/s0190-9622(81)70130-0.
Crohn's disease is a chronic inflammatory bowel disease which may have distinctive mucocutaneous manifestations. Included in this group are perianal, peristomal, and perifistular ulceration, as well as granulomatous cutaneous inflammation separate from gastrointestinal tract openings (metastatic Crohn's disease). In the oral cavity, both ulcerations and granulomatous nodules may occur. Malabsorption of nutrients may lead to several changes, including an acrodermatitis enteropathica-like syndrome secondary to zinc deficiency. Patients with Crohn's disease may also have pyoderma gangrenosum, erythema nodosum, cutaneous vasculitis, and other less specific changes.
克罗恩病是一种慢性炎症性肠病，可能有独特的黏膜皮肤表现。这一组表现包括肛周、造口周围和瘘管周围溃疡，以及与胃肠道开口无关的肉芽肿性皮肤炎症（转移性克罗恩病）。在口腔中，可能出现溃疡和肉芽肿性结节。营养物质吸收不良可能导致多种变化，包括继发于锌缺乏的肠病性肢端皮炎样综合征。克罗恩病患者还可能有坏疽性脓皮病、结节性红斑、皮肤血管炎和其他不太特异的变化。
