Nakano R, Iwasaki M, Yamoto M
Gynecol Obstet Invest. 1985;20(1):45-51. doi: 10.1159/000298970.
Aqueous extracts of human luteal tissue significantly inhibited binding of 125I-labelled human luteinizing hormone (LH) to the 2,000-g subcellular fraction of human corpora lutea. In contrast, aqueous extract of nonluteal tissue of the human ovary did not show a comparable activity to inhibit LH binding. Extracts of human corpus luteum had little or no ability to inhibit LH binding to porcine luteal homogenates. The inhibitory effect of the aqueous extract on LH binding to human luteal homogenate was demonstrated to be dose-related. The inhibitory effect of aqueous extracts of human corpora lutea on LH binding increased from the early to mid and late luteal phase of the menstrual cycle. The results of the present study suggest that there is an LH receptor binding inhibitor (LHRBI) in the 30,000-g aqueous extract of the human corpus luteum and the increase in LHRBI in the luteal tissue as the human corpus luteum ages may explain the means whereby the human corpus luteum regulates its own life span.
人黄体组织的水提取物显著抑制125I标记的人促黄体生成素（LH）与人类黄体2000g亚细胞组分的结合。相比之下，人卵巢非黄体组织的水提取物未显示出类似的抑制LH结合的活性。人黄体提取物抑制LH与猪黄体匀浆结合的能力很小或没有。水提取物对LH与人黄体匀浆结合的抑制作用呈剂量相关。人黄体水提取物对LH结合的抑制作用在月经周期的黄体早期到中期和晚期有所增加。本研究结果表明，人黄体30000g水提取物中存在LH受体结合抑制剂（LHRBI），随着人黄体老化，黄体组织中LHRBI的增加可能解释了人黄体调节自身寿命的方式。
