Department of Nano-Bioengineering, Incheon National University, Incheon, 22012, South Korea.
School of Electrical & Electronic Engineering, Yonsei University, Seoul, 03722, South Korea.
Small. 2018 Jul;14(30):e1801732. doi: 10.1002/smll.201801732. Epub 2018 Jun 27.
Penetrating electronics have been used for treating epilepsy, yet their therapeutic effects are debated largely due to the lack of a large-scale, real-time, and safe recording/stimulation. Here, the proposed technology integrates ultrathin epidural electronics into an electrocorticography array, therein simultaneously sampling brain signals in a large area for diagnostic purposes and delivering electrical pulses for treatment. The system is empirically tested to record the ictal-like activities of the thalamocortical network in vitro and in vivo using the epidural electronics. Also, it is newly demonstrated that the electronics selectively diminish epileptiform activities, but not normal signal transduction, in live animals. It is proposed that this technology heralds a new generation of diagnostic and therapeutic brain-machine interfaces. Such an electronic system can be applicable for several brain diseases such as tinnitus, Parkinson's disease, Huntington's disease, depression, and schizophrenia.
穿透式电子设备已被用于治疗癫痫，但由于缺乏大规模、实时和安全的记录/刺激，其治疗效果仍存在争议。在这里，所提出的技术将超轻薄的硬膜外电子设备集成到脑电图阵列中，以便同时在大面积范围内进行诊断目的的脑信号采样和传递电脉冲进行治疗。该系统经过实证测试，使用硬膜外电子设备在体外和体内记录丘脑皮质网络的类似癫痫发作活动。此外，新的研究表明，该电子设备可选择性地减少活体动物中的癫痫样活动，而不会影响正常的信号转导。据提议，该技术预示着新一代诊断和治疗性脑机接口的出现。这种电子系统可适用于多种脑部疾病，如耳鸣、帕金森病、亨廷顿病、抑郁症和精神分裂症等。
