Goetz Stephen, Pritts Benjamin, Cornelius Bryant
Resident, Department of Dental Anesthesiology, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania, and.
Assistant Professor, Section of Dental/Maxillofacial Anesthesiology, The Ohio State University College of Dentistry, Columbus, Ohio.
Anesth Prog. 2018 Summer;65(2):113-118. doi: 10.2344/anpr-65-03-03.
Sugammadex is a novel drug capable of reversing paralysis induced by the common steroidal nondepolarizing neuromuscular blocking drugs, rocuronium and vecuronium. Reversal is complete at any depth of blockade dependent on the dose of sugammadex administered. This allows rocuronium to be used as a rescue agent in scenarios where succinylcholine is contraindicated. Sugammadex is considered a safe drug with minimal side effects compared with traditional reversal with neostigmine and glycopyrrolate. This article features a case report where succinylcholine was undesirable and rapid reversal of paralysis with sugammadex was used during general anesthesia for dentistry.
舒更葡糖钠是一种新型药物,能够逆转常见的甾体类非去极化神经肌肉阻滞药物罗库溴铵和维库溴铵所致的麻痹。根据所给予的舒更葡糖钠剂量,在任何阻滞深度下均可实现完全逆转。这使得罗库溴铵可在琥珀酰胆碱禁忌的情况下用作急救药物。与使用新斯的明和格隆溴铵进行传统逆转相比,舒更葡糖钠被认为是一种安全且副作用极小的药物。本文报道了一例在牙科全身麻醉期间琥珀酰胆碱不适用且使用舒更葡糖钠快速逆转麻痹的病例。