Liu Xiao-Ni, Pang Jing
Department of Endocrinology, The People's Hospital of Yan'an Department of Endocrinology, Affiliated Hospital of Yan'an University, Yan'an, China.
Medicine (Baltimore). 2018 Jun;97(26):e10819. doi: 10.1097/MD.0000000000010819.
This study investigated the effect of supplemental iron intake (SII) in early singleton pregnancy women with the risk of developing gestational diabetes mellitus (GDM) among Chinese population.This study included 259 singleton pregnancy participants. Of those, 135 women underwent SII and were assigned to an intervention group, while 124 participants received no SII and were assigned to a control group. The outcome measurements consisted of the number of patients with GDM development, the levels of hemoglobin (Hb) and ferritin, and the outcomes of infant at delivery.No significant difference in the number of patients with GDM development was found between 2 groups at delivery. However, when compared with control group, subjects in the intervention group showed greater efficacy in delivery mode choice of vaginal delivery (P = .04), and cesarean section (P = .01), as well as the birthweight of infants (P < .01). Moreover, Hb and ferritin levels were also significantly higher in the intervention group than those in the control group (P < .01).The results of this retrospective study showed that SII may not increase risk of developing GDM in singleton pregnancy women; and also may benefit both pregnancy women and infants among Chinese population.
本研究调查了中国人群中早期单胎妊娠且有患妊娠期糖尿病（GDM）风险的女性补充铁摄入（SII）的效果。本研究纳入了259名单胎妊娠参与者。其中，135名女性进行了SII并被分配到干预组，而124名参与者未进行SII并被分配到对照组。结局指标包括发生GDM的患者数量、血红蛋白（Hb）和铁蛋白水平以及分娩时婴儿的结局。分娩时两组发生GDM的患者数量无显著差异。然而，与对照组相比，干预组受试者在阴道分娩（P = 0.04）和剖宫产（P = 0.01）的分娩方式选择以及婴儿出生体重方面（P < 0.01）显示出更大的效果。此外，干预组的Hb和铁蛋白水平也显著高于对照组（P < 0.01）。这项回顾性研究的结果表明，SII可能不会增加单胎妊娠女性患GDM的风险；并且在中国人群中对孕妇和婴儿都可能有益。
