Javadian Pouya, Alimohamadi Shohreh, Gharedaghi Mohammad Hadi, Hantoushzadeh Sedigheh
Maternal-Fetal & Neonatal Research Center & Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
Department of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Acta Med Iran. 2014;52(5):385-9.
The possible effect of iron supplementation has been investigated in the normal population and patients with gestational diabetes mellitus (GDM). In this study, we survey the risk factors of GDM in pregnant women in contrast with normoglycemic patients in a case control study in patients using iron supplement. This case control study conducted on 52 pregnant women with GDM (25 women with type Al and 27 women with Type A2 of GDM). The control group randomly selected 50 normoglycemic women. Venous blood sampling was done between 24 and 28 weeks of pregnancy for measuring of ferritin, lipoproteins, uric acid and malondialdehyde serum levels. Under study variables including age, gestational age, weight and BMI were gathered. All the women were followed up until the time of delivery and pregnancy outcome were gathered. The serum ferritin levels in GDM group was 31.22+15.44, which is significantly higher than 24.76+8.94, in the control group with (P=0.012). Plasma hemogulobin in the control group was 12.2+0.1 compared to 12.9+0.1 in GDM group which was significantly lower (P=0.005). Triglycerides was significantly higher in GDM group in contrast with the control group, 275.08+143.17 and 192.30+92.13 (P=0.001), respectively. Finally, our findings indicate the concentration of serum ferritin levels was significantly higher in The GDM group.
铁补充剂的潜在影响已在正常人群和妊娠期糖尿病（GDM）患者中进行了研究。在本研究中，我们在一项针对使用铁补充剂的患者的病例对照研究中，调查了孕妇患GDM的危险因素，并与血糖正常的患者进行对比。这项病例对照研究对52名患有GDM的孕妇（25名A1型和27名A2型GDM孕妇）进行。对照组随机选取了50名血糖正常的女性。在妊娠24至28周期间采集静脉血样，以测量血清铁蛋白、脂蛋白、尿酸和丙二醛水平。收集研究中的变量，包括年龄、孕周、体重和BMI。所有女性均随访至分娩时，并收集妊娠结局。GDM组的血清铁蛋白水平为31.22±15.44，显著高于对照组的24.76±8.94（P = 0.012）。对照组的血浆血红蛋白为12.·2±0.1，而GDM组为12.9±0.1，显著更低（P = 0.005）。与对照组相比，GDM组的甘油三酯显著更高，分别为275.08±143.17和192.30±92.13（P = 0.001）。最后，我们的研究结果表明，GDM组的血清铁蛋白水平浓度显著更高。
