Department of Oral Implantology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Department of Oral Implantology, Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
J Clin Periodontol. 2018 Sep;45(9):1118-1127. doi: 10.1111/jcpe.12975. Epub 2018 Jul 27.
To evaluate endo-sinus new bone formation and implant osseointegration after transalveolar sinus floor elevation (TSFE) and simultaneous implant placement without any grafting materials and to investigate the influence of implant surface modification on bone healing process under this circumstance.
Transalveolar sinus floor elevation and simultaneous implant placement were conducted bilaterally on 12 Labrador dogs. No grafting materials were used during surgery. Implants with two different surfaces (SLA and SLActive) were placed in a split-mouth design. The animals were sacrificed 4, 8 and 24 weeks after surgery for histological and histomorphometric assessments. Bone-to-implant contact (BIC%), alveolar bone height (ABH) and the percentages of mineralized bone (MB%) in the area of interest were analysed. The probing depth (PD) and bleeding on probing (BOP) were also assessed to describe peri-implant health conditions.
Sprouts of new bone in direct contact with implant surface were seen in the elevated area at every time point. Newly formed woven bone under sinus membrane was visible. SLActive implants exhibited favourable results compared with SLA implants regarding ABH at 4 weeks and BIC% at 4 and 8 weeks. Sites with BOP positive could be observed in both groups at any time point. No newly formed bone can be found on the implant apex with either SLA or SLActive surfaces at any time point.
Spontaneous new bone formation from the parent bone walls could be observed after TFE without any grafting materials. No clear evidence of bone formation from the Schneiderian membrane could be found. Even though there were trends for quicker bone response of SLActive implants, this study failed to show the absolute advantage of SLActive in achieving endo-sinus bone formation.
评估经牙槽嵴窦底提升（TSFE）和同期种植时无任何植骨材料的情况下，种植体周围新骨形成和骨整合情况，并研究在这种情况下种植体表面改性对骨愈合过程的影响。
在 12 只拉布拉多犬双侧行经牙槽嵴窦底提升和同期种植，术中不使用任何植骨材料。采用劈开设计分别将两种不同表面（SLA 和 SLActive）的种植体植入。术后 4、8 和 24 周处死动物，进行组织学和组织形态计量学评估。分析感兴趣区域的骨-种植体接触率（BIC%）、牙槽骨高度（ABH）和矿化骨百分比（MB%）。还评估了探诊深度（PD）和探诊出血（BOP），以描述种植体周围健康状况。
在每个时间点，提升区域都可见与种植体表面直接接触的新骨芽。在窦膜下可见新生编织骨。与 SLA 种植体相比，SLActive 种植体在 4 周时的 ABH 和 4、8 周时的 BIC%方面表现出更好的结果。在任何时间点，两个组都可观察到 BOP 阳性的部位。在任何时间点，SLA 或 SLActive 表面的种植体根尖都没有发现新骨形成。
在无任何植骨材料的情况下，TFE 后可观察到来自母体骨壁的自发性新骨形成。未发现来自黏膜的明确骨形成证据。尽管 SLActive 种植体有更快的骨反应趋势，但本研究未能证明 SLActive 在实现窦内骨形成方面具有绝对优势。
