Zhao Qian, Wang Bin, Liu Ruifeng, Gong Ming, Dong Mingfeng, Fang Minglan, Jiang Tingshun
J Nanosci Nanotechnol. 2018 Oct 1;18(10):7225-7230. doi: 10.1166/jnn.2018.15507.
The doxorubicin hydrochloride (DOX)-loaded poly(L-lactic acid)/hydroxyapatite/gelatin (PLLA/a-HA/gelatin) particle was prepared by emulsion/solvent evaporation method using CH2Cl2 as a solvent. HA nanoparticles were prepared via a facile chemical precipitate method and HA nanoparticles were functionalized by adding aminopropyltriethoxysilane (APTS) under microwave radiation. The physical and chemical properties of HA and modified HA were characterized by XRD, TEM, FT-IR, and XPS. Furthermore, the release of DOX from PLLA/a-HA/gelatin was also estimated. Results indicated that HA was successfully functionalized via APTS and functionalized HA has primary amino groups on its surface which improved the surface chemical compatibility between HA and PLLA matrix. The prepared PLLA/a-HA/gelatin was considered as a drug release carrier to study sustained release behavior of doxorubicin hydrochloride (DOX). The PLLA/a-HA/gelatin can effectively prolong the release time of DOX and exhibits a stable and sustainable drug release which indicates that the PLLA/a-HA/gelatin nanocomposite material could serve as a potential carrier for novel drug release system.
采用乳液/溶剂挥发法，以二氯甲烷为溶剂制备了负载盐酸阿霉素（DOX）的聚（L-乳酸）/羟基磷灰石/明胶（PLLA/α-HA/明胶）颗粒。通过简便的化学沉淀法制备了HA纳米颗粒，并在微波辐射下通过添加氨丙基三乙氧基硅烷（APTS）对HA纳米颗粒进行功能化。采用XRD、TEM、FT-IR和XPS对HA及改性HA的物理化学性质进行了表征。此外，还评估了DOX从PLLA/α-HA/明胶中的释放情况。结果表明，HA通过APTS成功实现了功能化，功能化HA表面具有伯氨基，改善了HA与PLLA基质之间的表面化学相容性。制备的PLLA/α-HA/明胶被视为药物释放载体，用于研究盐酸阿霉素（DOX）的缓释行为。PLLA/α-HA/明胶能够有效延长DOX的释放时间，并呈现出稳定且持续的药物释放，这表明PLLA/α-HA/明胶纳米复合材料可作为新型药物释放系统的潜在载体。
