Drug Release Behavior of Doxorubicin Hydrochloride-Loaded Poly(-Lactic Acid)/Hydroxyapatite/Gelatin by Surface Modification of Hydroxyapatite.

The doxorubicin hydrochloride (DOX)-loaded poly(L-lactic acid)/hydroxyapatite/gelatin (PLLA/a-HA/gelatin) particle was prepared by emulsion/solvent evaporation method using CH2Cl2 as a solvent. HA nanoparticles were prepared via a facile chemical precipitate method and HA nanoparticles were functionalized by adding aminopropyltriethoxysilane (APTS) under microwave radiation. The physical and chemical properties of HA and modified HA were characterized by XRD, TEM, FT-IR, and XPS. Furthermore, the release of DOX from PLLA/a-HA/gelatin was also estimated. Results indicated that HA was successfully functionalized via APTS and functionalized HA has primary amino groups on its surface which improved the surface chemical compatibility between HA and PLLA matrix. The prepared PLLA/a-HA/gelatin was considered as a drug release carrier to study sustained release behavior of doxorubicin hydrochloride (DOX). The PLLA/a-HA/gelatin can effectively prolong the release time of DOX and exhibits a stable and sustainable drug release which indicates that the PLLA/a-HA/gelatin nanocomposite material could serve as a potential carrier for novel drug release system.