Department of Applied Mechanics, Sichuan University, Chengdu, China.
College of Architecture & Environment, Sichuan University, Chengdu, China.
J Vasc Surg. 2019 Feb;69(2):581-591.e1. doi: 10.1016/j.jvs.2018.02.033. Epub 2018 Jun 25.
This article compares the effect of different surfactants on foam stability and determines the foam decay relationship, so that the suitability of surfactants in a clinical setting can be evaluated.
Five different surfactants were used to prepare sclerosing foam at room temperature using a liquid:gas ratio of 1:4 in vitro. Foam decay experiments were performed for each sample using a laboratory-made foaming apparatus, and the process was recorded using a video camera. The stability indices used included the drainage time, drainage rate, half-life, foam half-life volume, surfactant stability index, and foaming index.
The sodium morrhuate foam was relatively more stable than the polidocanol foam, but exhibited weak foaming. After the addition of the surfactants, the foam half-life was less than 300 seconds. The effect of the surfactants on the stability of the sodium morrhuate foam was more pronounced. The surfactant stability indices could be arranged as follows: poloxamer 188 > Tween 80 > macrogol 4000 > propanediol > lecithin. However, the differences in the foaming indices were small.
Of the five surfactants tested, poloxamer 188 has best performance to enhance sclerosing foam stability. The addition of the surfactants improved the stability of the sclerosing foams. It was observed that the relationships between the foam half-life and the surfactant stability index and the surfactant concentration follow the power law.
本文比较了不同表面活性剂对泡沫稳定性的影响，并确定了泡沫衰减关系，从而评估表面活性剂在临床环境中的适用性。
在体外使用液体：气体比为 1：4，使用 5 种不同的表面活性剂来制备室温下的硬化泡沫。使用实验室自制的发泡装置对每个样品进行泡沫衰减实验，并使用摄像机记录过程。稳定性指数包括排水时间、排水率、半衰期、泡沫半衰期体积、表面活性剂稳定性指数和发泡指数。
与聚多卡醇泡沫相比，鱼精蛋白泡沫相对更稳定，但发泡能力较弱。加入表面活性剂后，泡沫半衰期小于 300 秒。表面活性剂对鱼精蛋白泡沫稳定性的影响更为明显。表面活性剂稳定性指数可排列如下：泊洛沙姆 188＞吐温 80＞聚乙二醇 4000＞丙二醇＞卵磷脂。然而，发泡指数的差异较小。
在测试的 5 种表面活性剂中，泊洛沙姆 188 增强硬化泡沫稳定性的性能最佳。添加表面活性剂可提高硬化泡沫的稳定性。观察到泡沫半衰期与表面活性剂稳定性指数和表面活性剂浓度之间的关系遵循幂律。
