Berlin I
Département de pharmacologie, CESP-Inserm 1018, hôpital Pitié-Salpêtrière, faculté de médecine,Sorbonne université, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
Rev Mal Respir. 2018 Jun;35(6):686-693. doi: 10.1016/j.rmr.2017.11.011. Epub 2018 Jun 25.
Maternal smoking during pregnancy (MSDP) is a well-established risk factor for negative pregnancy outcomes, but its negative effects on the health of the child after birth are less well known by both health professionals and the general public. Large cohort studies over the past 10 years have shown that MSDP is an independent risk factor for several childhood health problems such as e.g. obesity and smoking. A large number of recent studies and 3 meta-analyses demonstrate that MSDP is an independent risk factor of wheezing and asthma of the child exposed in utero to maternal smoking. MSDP is associated with epigenetic toxicities the currently most plausible hypothesis to explain the diversity of its postnatal negative effects. The eradication of MSDP could contribute to the reduction of health problems in the next generation, including the incidence of childhood respiratory disorders.
孕期母亲吸烟（MSDP）是导致不良妊娠结局的一个公认风险因素，但其对孩子出生后健康的负面影响，无论是医疗专业人员还是普通大众都了解得较少。过去十年的大型队列研究表明，MSDP是导致多种儿童健康问题的独立风险因素，比如肥胖和吸烟。近期大量研究及三项荟萃分析表明，MSDP是子宫内暴露于母亲吸烟环境的儿童出现喘息和哮喘的独立风险因素。MSDP与表观遗传毒性有关，这是目前最合理的假设，用以解释其出生后负面影响的多样性。消除MSDP有助于减少下一代的健康问题，包括儿童呼吸系统疾病的发病率。
