Kelly Michael E, Mohan Helen M, Baird Alan W, Ryan Elizabeth J, Winter Des C
UCD Veterinary Sciences Centre, University College Dublin, Dublin 4, Ireland.
Centre for Colorectal Disease, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Pathol Oncol Res. 2018 Oct;24(4):815-819. doi: 10.1007/s12253-018-0440-6. Epub 2018 Jun 28.
Colorectal cancer is one of the most common cancers worldwide, with an overall increased incidence annually. Despite improvements in treatment and surveillance, almost 50% develop recurrent and/or distant disease. Unknown cellular processes are the fundamental cause for treatment failure and metastatic disease. The interplay of chronic inflammation and carcinogenesis is well established. Recent work has highlighted the role of nuclear receptors and co-regulators in the inflammation to carcinogenesis process. Orphan nuclear receptors have been shown to be involved in numerous cellular processes, including both at a transcriptional and a non-genomic level. There is a significant emphasis to identify ligands that will interact and modify these nuclear receptors, with the long-term aim of developing novel pharmaceutical therapies. The identification of orphan nuclear receptor ligands will also help increase our current understanding of their role in cellular signaling, by enabling manipulation of these receptors. This review aims to provide a brief overview of some key orphan nuclear receptors which may be involved in colorectal cancer.
结直肠癌是全球最常见的癌症之一，其总体发病率每年都在上升。尽管治疗和监测有所改善，但仍有近50%的患者会出现复发和/或远处疾病。未知的细胞过程是治疗失败和转移性疾病的根本原因。慢性炎症与致癌作用之间的相互作用已得到充分证实。最近的研究突出了核受体和共调节因子在炎症到致癌过程中的作用。已证明孤儿核受体参与众多细胞过程，包括转录水平和非基因组水平。人们非常重视识别能够与这些核受体相互作用并对其进行修饰的配体，其长期目标是开发新的药物疗法。识别孤儿核受体配体也将有助于通过对这些受体的操控，加深我们目前对它们在细胞信号传导中作用的理解。本综述旨在简要概述一些可能与结直肠癌相关的关键孤儿核受体。
