Department of Obstetrics and Gynecology, Medical Park Hospital, 35575, Izmir, Turkey.
Department of Obstetrics and Gynecology, Izmir Tepecik Training and Research Hospital, Tepecik, 35120, Izmir, Turkey.
J Endocrinol Invest. 2019 Mar;42(3):303-312. doi: 10.1007/s40618-018-0917-x. Epub 2018 Jun 28.
Insulin-like peptide 5 (INSL5) is a gut peptide hormone that is a member of relaxin/insulin superfamily. Growing evidence implicates the crucial role of the peptide in some metabolisms including food intake, glucose homeostasis and reproductive system. Polycystic ovary syndrome (PCOS) is involved in both reproductive and metabolic issues. The aim of the study was determination of circulating levels of INSL5 alteration in women with PCOS and evaluation of the relationship between INSL5 and hormonal-metabolic parameters as well as carotid intima media thickness (cIMT).
A total of 164 subjects were recruited in this cross-sectional study (82 women with PCOS and 82 age- and BMI-matched controls). Circulating INSL5 levels were assessed via ELISA method. High-resolution B-mode ultrasound was used to measure cIMT. The hormonal and metabolic parameters of the recruited subjects were determined.
Circulating INSL5 levels were significantly elevated in women with PCOS compared to controls (27.63 ± 7.74 vs. 19.90 ± 5.85 ng/ml, P < 0.001). The mean values of INSL5 were significantly higher in overweight subjects compared to lean weight subjects in both groups. The women with PCOS having insulin resistance have increased INSL5 compared to those of PCOS subjects without insulin resistance. INSL5 is associated with insulin resistance, BMI, luteinizing hormone and free androgen index. Multivariate logistic regression analyses revealed that the odds ratio for having PCOS in the highest tertile of INSL5 was higher than in the lowest tertile.
PCOS subjects exhibited an elevation in circulating INSL5 levels along with a link between INSL5 level induction and metabolic-hormonal parameters.
胰岛素样肽 5（INSL5）是一种肠道肽类激素，属于松弛素/胰岛素超家族的成员。越来越多的证据表明，该肽在一些代谢过程中起着关键作用，包括摄食、葡萄糖稳态和生殖系统。多囊卵巢综合征（PCOS）涉及生殖和代谢问题。本研究的目的是确定 PCOS 妇女循环 INSL5 水平的变化，并评估 INSL5 与激素代谢参数以及颈动脉内膜中层厚度（cIMT）之间的关系。
本研究为横断面研究，共纳入 164 例受试者（82 例 PCOS 妇女和 82 例年龄和 BMI 匹配的对照者）。采用 ELISA 法测定循环 INSL5 水平。使用高分辨率 B 型超声测量 cIMT。对纳入研究对象的激素和代谢参数进行测定。
与对照组相比，PCOS 妇女的循环 INSL5 水平显著升高（27.63±7.74 比 19.90±5.85ng/ml，P<0.001）。两组中，超重受试者的 INSL5 平均值均高于体重正常受试者。与无胰岛素抵抗的 PCOS 患者相比，胰岛素抵抗的 PCOS 患者的 INSL5 升高。INSL5 与胰岛素抵抗、BMI、促黄体生成素和游离雄激素指数相关。多变量逻辑回归分析显示，INSL5 最高三分位组发生 PCOS 的比值比高于最低三分位组。
PCOS 患者表现出循环 INSL5 水平升高，且 INSL5 水平升高与代谢-激素参数相关。
