Karbek Basak, Ozbek Mustafa, Karakose Melia, Topaloglu Oya, Bozkurt Nujen Colak, Cakır Evrim, Aslan Muyesser Sayki, Delibasi Tuncay
Department of Endocrinology and Metabolic Diseases, Gaziantep Dr, Ersin Arslan Hospital, Milli Egemenlik bulvarı, Sanlılar Apt, no:51 daire:9 Şehitkamil/Gaziantep, Gaziantep, Turkey.
J Ovarian Res. 2014 Mar 14;7:31. doi: 10.1186/1757-2215-7-31.
Women with polycystic ovary syndrome (PCOS) have higher risk for cardiovascular disease (CVD). Copeptin has been found to be predictive for myocardial ischemia. We tested whether copeptin is the predictor for CVD in PCOS patients, who have an increased risk of cardiovascular disease.
This was a cross sectional controlled study conducted in a training and research hospital. The study population consisted of 40 reproductive-age PCOS women and 43 control subjects. We evaluated anthropometric and metabolic parameters, carotid intima media thickness and copeptin levels in both PCOS patients and control group.
Mean fasting insulin, homeostasis model assessment insulin resistance index (HOMA-IR), triglyceride, total cholesterol, low density lipoprotein cholesterol (LDL-C), free testosterone, 17-OH progesterone, Dehydroepiandrosterone sulfate (DHEAS), carotid intima media thickness (CIMT) levels were significantly higher in PCOS patients. Mean copeptin level was in 12.61 ± 3.05 pmol/L in PCOS patients while mean copeptin level was 9.60 ± 2.80 pmol/L in healthy control women (p < 0.001). After adjustment for age and BMI, copeptin level was positive correlated with fasting insulin, free testosterone levels, CIMT, and HOM A-IR.
Copeptin appeared to have an important role in metabolic response and subsequent development of atherosclerosis in insulin resistant, hyperandrogenemic PCOS patients.
多囊卵巢综合征（PCOS）女性患心血管疾病（CVD）的风险更高。已发现 copeptin 可预测心肌缺血。我们测试了 copeptin 是否为 PCOS 患者心血管疾病的预测指标，这些患者患心血管疾病的风险增加。
这是一项在一家培训和研究医院进行的横断面对照研究。研究人群包括 40 名育龄 PCOS 女性和 43 名对照受试者。我们评估了 PCOS 患者和对照组的人体测量和代谢参数、颈动脉内膜中层厚度和 copeptin 水平。
PCOS 患者的平均空腹胰岛素、稳态模型评估胰岛素抵抗指数（HOMA-IR）、甘油三酯、总胆固醇、低密度脂蛋白胆固醇（LDL-C）、游离睾酮、17-羟孕酮、硫酸脱氢表雄酮（DHEAS）、颈动脉内膜中层厚度（CIMT）水平显著更高。PCOS 患者的平均 copeptin 水平为 12.61±3.05 pmol/L，而健康对照女性的平均 copeptin 水平为 9.60±2.80 pmol/L（p<0.001）。在调整年龄和体重指数后，copeptin 水平与空腹胰岛素、游离睾酮水平、CIMT 和 HOMA-IR 呈正相关。
Copeptin 在胰岛素抵抗、高雄激素血症的 PCOS 患者的代谢反应和随后的动脉粥样硬化发展中似乎起重要作用。
