Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France.
Paris Translational Research Center for Organ Transplantation, French National institute of Health and Medical Research (INSERM). Unit UMR S970, Paris, France.
Am J Transplant. 2019 Jan;19(1):21-31. doi: 10.1111/ajt.14990. Epub 2018 Aug 1.
The Lung session of the 2017 14th Banff Foundation for Allograft Pathology Conference, Barcelona focused on the multiple aspects of antibody-mediated rejection (AMR) in lung transplantation. Multidimensional approaches for AMR diagnosis, including classification, histological and immunohistochemical analysis, and donor- specific antibody (DSA) characterization with their current strengths and limitations were reviewed in view of recent research. The group also discussed the role of tissue gene expression analysis in the context of unmet needs in lung transplantation. The current best practice for monitoring of AMR and the therapeutic approach are summarized and highlighted in this report. The working group reached consensus of the major gaps in current knowledge and focused on the unanswered questions regarding pulmonary AMR. An important outcome of the meeting was agreement on the need for future collaborative research projects to address these gaps in the field of lung transplantation.
2017 年第 14 届巴塞尔同种异体移植病理学基金会会议的肺会议重点关注了肺移植中抗体介导排斥反应 (AMR) 的多个方面。在考虑到最近的研究的情况下，该小组回顾了 AMR 诊断的多维方法，包括分类、组织学和免疫组织化学分析，以及供体特异性抗体 (DSA) 的特征及其当前的优势和局限性。该小组还讨论了组织基因表达分析在肺移植未满足需求方面的作用。本报告总结和强调了目前监测 AMR 和治疗方法的最佳实践。工作组就当前知识的主要差距达成了共识，并集中讨论了关于肺 AMR 的未解决问题。会议的一个重要成果是，一致认为需要开展未来的合作研究项目来解决肺移植领域的这些差距。
