Dehkordi Azar B, Sanei Behnam, Yousefi Morteza, Sharafi Seyedeh M, Safarnezhad Farhang, Jafari Rasool, Darani Hossein Y
Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Hepatobiliary Surgery, Isfahan University of Medical Sciences, Isfahan, Iran.
Infect Disord Drug Targets. 2019;19(2):101-104. doi: 10.2174/1871526518666180629134511.
Human hydatid cyst or cystic echinococcosis is a life-threatening zoonotic disease that occurs in most countries worldwide and is recognized as a major public health problem. Following ingestion of Echinococcus granulosus eggs, hydatid cysts which are the larval stage of the worm are formed mostly in liver and lungs, and occasionally in other organs of human. The usual treatment for hydatid cyst is open surgery. One of the problems following surgery is the recurrence. In the last decades, albendazole has been used for the treatment of hydatid cyst. This drug can be used alone or jointly with surgical procedures. However, its efficacy has not been well documented. Thus, in this work, the treatment of hydatid cyst with albendazole in different investigations including case studies, clinical trials in human and experimental works in animals has been reviewed. According to the findings of this review, it can be concluded that treatment of hydatid cyst with albendazole may be associated with the prevention of recurrence and reduction of the size and death of the hydatid cysts.
人类包虫囊肿或囊性棘球蚴病是一种危及生命的人畜共患病，在世界上大多数国家都有发生，被公认为是一个重大的公共卫生问题。摄入细粒棘球绦虫卵后，作为该蠕虫幼虫阶段的包虫囊肿主要在肝脏和肺部形成，偶尔也会在人体的其他器官形成。包虫囊肿的常规治疗方法是开放性手术。手术后的问题之一是复发。在过去几十年中，阿苯达唑已被用于治疗包虫囊肿。这种药物可以单独使用，也可以与手术联合使用。然而，其疗效尚未得到充分证明。因此，在这项工作中，我们回顾了在不同研究中，包括病例研究、人体临床试验和动物实验中，使用阿苯达唑治疗包虫囊肿的情况。根据本次综述的结果，可以得出结论，用阿苯达唑治疗包虫囊肿可能与预防复发、减小包虫囊肿的大小以及使其死亡有关。
