一种可行的策略，用于筛选糖基异质性对活鼠靶器官黏附和生物分布的影响。
A viable strategy for screening the effects of glycan heterogeneity on target organ adhesion and biodistribution in live mice.
机构信息
Biofunctional Synthetic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
出版信息
Chem Commun (Camb). 2018 Aug 2;54(63):8693-8696. doi: 10.1039/c8cc01544a.
PMID:29956701
Abstract
This work represents the first broad study of testing diverse heterogenous glycoconjugates (7 different glycoalbumins) for their differential in vivo binding (11 different cancer cell types) in both cell- and animal-based studies. As a result, various changes in biodistribution, excretion, and even tumor adhesion were observed.
摘要
这项工作代表了首次广泛研究不同异质糖缀合物（7 种不同糖白蛋白）在细胞和动物基础研究中的体内结合（11 种不同癌症细胞类型）的差异。因此，观察到生物分布、排泄甚至肿瘤黏附的各种变化。
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