体内活体小鼠中的金复合物催化作用。
In Vivo Gold Complex Catalysis within Live Mice.
机构信息
Biofunctional Synthetic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan.
出版信息
Angew Chem Int Ed Engl. 2017 Mar 20;56(13):3579-3584. doi: 10.1002/anie.201610273. Epub 2017 Feb 15.
Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin-Au complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.
金属配合物催化在生物体系中主要局限于细胞和细菌体系。在这项工作中，设计并开发了一种糖白蛋白-金配合物，使活小鼠体内的特定器官、局部炔丙基酯酰胺化与附近的蛋白质成为可能。通过使用 Cy7.5 和 TAMRA 连接的炔丙基酯基荧光探针可以对靶向反应性进行成像。这种靶向系统可以为生物医学和临床应用中其他金属催化策略的开发提供可能性。
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