Application of Claisen Rearrangement and Olefin Metathesis in Organic Synthesis.

Several new synthetic methods to diverse polycycles and heterocycles on the basis of [3,3]-sigmatropic rearrangement and ring-closing metathesis as key steps are summarized. In this regard, Claisen, aza-Claisen, and Overman rearrangements are used in combination with other popular reactions such as ring-closing metathesis, Suzuki coupling, Diels-Alder reaction, and retro-Diels-Alder reaction. To this end, we prepared polycycles (e.g., cyclophanes, cage molecules), heterocycles (e.g., oxepins, azapins), carbocycles, and spirocycles with the use of the above protocol.