Kotha Sambasivarao, Meshram Milind
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-, 400 076, India.
Chem Asian J. 2018 Jun 29. doi: 10.1002/asia.201800613.
Several new synthetic methods to diverse polycycles and heterocycles on the basis of [3,3]-sigmatropic rearrangement and ring-closing metathesis as key steps are summarized. In this regard, Claisen, aza-Claisen, and Overman rearrangements are used in combination with other popular reactions such as ring-closing metathesis, Suzuki coupling, Diels-Alder reaction, and retro-Diels-Alder reaction. To this end, we prepared polycycles (e.g., cyclophanes, cage molecules), heterocycles (e.g., oxepins, azapins), carbocycles, and spirocycles with the use of the above protocol.
总结了几种基于[3,3] - 迁移重排和关环复分解作为关键步骤来合成多种多环和杂环化合物的新方法。在这方面，克莱森重排、氮杂克莱森重排和奥弗曼重排与其他常用反应如关环复分解、铃木偶联反应、狄尔斯 - 阿尔德反应和逆狄尔斯 - 阿尔德反应结合使用。为此，我们使用上述方法制备了多环化合物（如环芳烷、笼状分子）、杂环化合物（如氧杂环庚三烯、氮杂环庚三烯）、碳环化合物和螺环化合物。
