合成并提出一种新的纳米金（III）褪黑素药物配合物：睾丸保护的有趣模型。

Synthesis and suggestion of a new nanometric gold(III) melatonin drug complex: an interesting model for testicular protection.

机构信息

Chemistry Department, Faculty of Science, Taif University, PO Box 888, Al-Hawiah, Taif 21974, Saudi Arabia.

Chemistry Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.

出版信息

Future Med Chem. 2018 Jul 1;10(14):1693-1704. doi: 10.4155/fmc-2018-0008. Epub 2018 Jun 29.

DOI:10.4155/fmc-2018-0008

PMID:29957063

Abstract

AIM

Melatonin (MLT) is a major hormone secreted by the pineal gland. In this study, a gold(III) MLT (Au/MLT) complex has been synthesized and investigating its protective effects against testicular damage.

METHODOLOGY

The structural features of the complex were investigated. For biological assessment, 30 male rats were divided into three groups for 30 days. The first control group, the second received MLT and the third received Au/MLT complex.

RESULTS

The Au/MLT complex was found to be nonelectrolytic with formula (Au[MLT][Cl][HO]). The ligand is monodentate and adopt square-planar geometry. Its particles range in diameter from 35 to 100 nm. MLT affords slight oxidative stress protection. The Au/MLT complex significantly decreases TNF-α and IL-1β levels but elevates antioxidant enzyme capacities, reducing lipid peroxidation markers and improving testicular histological structure.

CONCLUSION

The Au/MLT complex improves the anti-inflammatory actions of MLT, exhibits potent antioxidant activity and enhances reproductive capacity.

摘要

目的

褪黑素（MLT）是松果腺分泌的主要激素。本研究合成了一种金（III）MLT（Au/MLT）配合物，并研究了其对睾丸损伤的保护作用。

方法

研究了配合物的结构特征。为了进行生物学评估，将 30 只雄性大鼠分为三组，持续 30 天。第一组为对照组，第二组给予 MLT，第三组给予 Au/MLT 配合物。

结果

Au/MLT 配合物为非电解质，化学式为（Au[MLT][Cl][HO]）。配体为单齿配位，采用平面正方形几何构型。其颗粒直径在 35 至 100nm 之间。MLT 提供轻微的氧化应激保护。Au/MLT 配合物可显著降低 TNF-α 和 IL-1β 水平，同时提高抗氧化酶的能力，减少脂质过氧化标志物，改善睾丸组织学结构。