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高速微粒子对明胶和合成水凝胶的影响。

High-velocity micro-particle impact on gelatin and synthetic hydrogel.

机构信息

Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

出版信息

J Mech Behav Biomed Mater. 2018 Oct;86:71-76. doi: 10.1016/j.jmbbm.2018.06.016. Epub 2018 Jun 14.

Abstract

The high-velocity impact response of gelatin and synthetic hydrogel samples is investigated using a laser-based microballistic platform for launching and imaging supersonic micro-particles. The micro-particles are monitored during impact and penetration into the gels using a high-speed multi-frame camera that can record up to 16 images with nanosecond time resolution. The trajectories are compared with a Poncelet model for particle penetration, demonstrating good agreement between experiments and the model for impact in gelatin. The model is further validated on a synthetic hydrogel and the applicability of the results is discussed. We find the strength resistance parameter in the Poncelet model to be two orders of magnitude higher than in macroscopic experiments at comparable impact velocities. The results open prospects for testing high-rate behavior of soft materials on the microscale and for guiding the design of drug delivery methods using accelerated microparticles.

摘要

利用基于激光的微弹道平台,采用发射和成像超音速微粒子的方法,研究了明胶和合成水凝胶样品的高速冲击响应。使用高速多帧相机在冲击和粒子穿透凝胶过程中监测微粒子,该相机可以以纳秒时间分辨率记录多达 16 张图像。将轨迹与粒子穿透的庞塞莱特模型进行了比较,结果表明在明胶冲击中,实验与模型吻合较好。进一步在合成水凝胶上验证了该模型,并讨论了结果的适用性。我们发现,在可比冲击速度下,庞塞莱特模型中的强度阻力参数比宏观实验中的高两个数量级。这些结果为在微尺度上测试软物质的高速行为以及使用加速微粒子指导药物输送方法的设计开辟了前景。

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