Ottenweller J E, Tapp W N, Burke J M, Natelson B H
Life Sci. 1985 Oct 21;37(16):1551-8. doi: 10.1016/0024-3205(85)90188-2.
Because some recent studies of hamster adrenocortical function have depended on older studies that may have been inadequate or misinterpreted, the present study re-examined plasma corticosterone and cortisol concentrations in hamsters under several conditions to determine which plasma glucocorticoid predominated in this animal. Sensitive radioimmunoassays were used to measure separately the two glucocorticoids in the basal condition, after adrenocorticotropin (ACTH) treatment, after acute stress, and after chronic stress. In the basal condition, corticosterone concentrations were 3-4 times higher than those of cortisol. After stimulation, this difference disappeared, but rarely were any hamster's cortisol levels higher than their corticosterone levels. Both ACTH and acute stress elevated plasma corticosterone and cortisol concentrations, but only plasma cortisol concentrations were elevated following chronic stress. The dissociation between cortisol and corticosterone concentrations after chronic stress suggests that the two glucocorticoid hormones in the hamster may be regulated independently. The data also indicate that both corticosterone and cortisol should be measured when assessing adrenocortical function in the hamster.
由于近期一些关于仓鼠肾上腺皮质功能的研究依赖于可能并不充分或存在误解的早期研究，本研究重新检测了仓鼠在几种情况下的血浆皮质酮和皮质醇浓度，以确定哪种血浆糖皮质激素在该动物中占主导地位。采用灵敏的放射免疫分析法分别测定基础状态下、促肾上腺皮质激素（ACTH）处理后、急性应激后和慢性应激后的两种糖皮质激素。在基础状态下，皮质酮浓度比皮质醇高3 - 4倍。刺激后，这种差异消失，但很少有仓鼠的皮质醇水平高于其皮质酮水平。ACTH和急性应激均升高了血浆皮质酮和皮质醇浓度，但慢性应激后仅血浆皮质醇浓度升高。慢性应激后皮质醇和皮质酮浓度的分离表明，仓鼠体内的两种糖皮质激素可能受到独立调节。数据还表明，在评估仓鼠肾上腺皮质功能时，应同时测量皮质酮和皮质醇。
