Vakili Hossein, Mohamadian Abdollah, Naderian Mohammadreza, Khaheshi Isa
Cardiovascular Research Center, Modarres hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran..
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran..
Acta Biomed. 2018 Jun 7;89(2):209-213. doi: 10.23750/abm.v89i2.5495.
Cystatin C, an endogenous indicator for kidney function, may be also an original indicator for coron Background and Aim: Cystatin C, an endogenous indicator for kidney function, may be also an original indicator for coronary atherosclerosis. In the current study, we intended to assess its role in establishing the existence of coronary artery disease. We also attempted to present the best cut off point for Cystatin C to discriminate coronary disease from normal coronary condition.
147 consecutive patients who were candidate for coronary angiography were included into the study. Cystatin C was measured using Auto-analyzer system and by Gentian kit with enzyme calorimetric method.
The mean level of Cystatin C in the patients with and without coronary artery disease was 0.97±0.51 mg/l and 1.02±0.40 mg/l with no significant difference (p=0.564). In multivariate logistic regression model, the serum level of Cystatin C could not predict coronary artery disease (OR=1.199, 95% CI: 0.531 to 1.706, p=0.662). According to the area under the ROC curve, Cystatin C was not a good indicator to discriminate coronary artery disease from normal coronary condition (AUC=0.465, 95% CI: 0.372 to 0.559, p=0.470). Considering cut of points of 0.85 and 0.94 for Cystatin C, the sensitivity of this test for predicting coronary artery disease in comparison with coronary angiography was 65% and 51%, respectively. In assessing relationship between serum level of Cystatin C and other chemical biomarkers, Cystatin C was only correlated with serum triglyceride level (r=0.207, p=0.012).
Cystatin C measurement may not be a suitable predictor for coronary artery disease and severity of the coronary involvement. Future studies with large sample size are necessitated to demarcate distinct role of Cystatin C in coronary artery disease. ary atherosclerosis. In the current study, we intended to assess its role in establishing the existence of coronary artery disease. We also attempted to present the best cut off point for Cystatin C to discriminate coronary disease from normal coronary condition.
147 consecutive patients who were candidate for coronary angiography were included into the study. Cystatin C was measured using Auto-analyzer system and by Gentian kit with enzyme calorimetric method. Results: The mean level of Cystatin C in the patients with and without coronary artery disease was 0.97 ± 0.51 mg/l and 1.02 ± 0.40 mg/l with no significant difference (p = 0.564). In multivariate logistic regression model, the serum level of Cystatin C could not predict coronary artery disease (OR = 1.199, 95% CI: 0.531 to 1.706, p = 0.662). According to the area under the ROC curve, Cystatin C was not a good indicator to discriminate coronary artery disease from normal coronary condition (AUC = 0.465, 95%CI: 0.372 to 0.559, p = 0.470). Considering cut of points of 0.85 and 0.94 for Cystatin C, the sensitivity of this test for predicting coronary artery disease in comparison with coronary angiography was 65% and 51%, respectively. In assessing relationship between serum level of Cystatin C and other chemical biomarkers, Cystatin C was only correlated with serum triglyceride level (r = 0.207, p = 0.012).
Cystatin C measurement may not be a suitable predictor for coronary artery disease and severity of the coronary involvement. Future studies with large sample size are necessitated to demarcate distinct role of Cystatin C in coronary artery disease.
胱抑素C是一种肾功能的内源性指标，也可能是冠状动脉粥样硬化的一个原始指标。在本研究中，我们旨在评估其在确定冠状动脉疾病存在方面的作用。我们还试图给出胱抑素C区分冠心病与正常冠状动脉状况的最佳截断点。
147例连续入选的拟行冠状动脉造影的患者纳入本研究。使用自动分析仪系统和龙胆试剂盒通过酶比色法测定胱抑素C。
有和无冠状动脉疾病患者的胱抑素C平均水平分别为0.97±0.51mg/L和1.02±0.40mg/L，无显著差异（p=0.564）。在多因素逻辑回归模型中，胱抑素C的血清水平不能预测冠状动脉疾病（OR=1.199，95%CI：0.531至1.706，p=0.662）。根据ROC曲线下面积，胱抑素C不是区分冠状动脉疾病与正常冠状动脉状况的良好指标（AUC=0.465，95%CI：0.372至0.559，p=0.470）。考虑胱抑素C的截断点为0.85和0.94时，该试验预测冠状动脉疾病与冠状动脉造影相比的敏感性分别为65%和51%。在评估胱抑素C血清水平与其他化学生物标志物之间的关系时，胱抑素C仅与血清甘油三酯水平相关（r=0.207，p=0.012）。
测定胱抑素C可能不是冠状动脉疾病及其严重程度的合适预测指标。需要进行大样本量的未来研究来明确胱抑素C在冠状动脉疾病中的独特作用。
