Yang Chi-Cheng, Lin Shinn-Yn, Tseng Chen-Kan
Department of Psychology, National Chengchi University , Taipei , Taiwan.
Department of Radiation Oncology, Chang Gung Memorial Hospital and Chang-Gung University , Taoyuan , Taiwan.
Appl Neuropsychol Child. 2019 Oct-Dec;8(4):389-395. doi: 10.1080/21622965.2018.1471996. Epub 2018 Jun 29.
Proton Beam Therapy (PBT) was developed to minimize the harmful results of radiation therapy as treatment for brain tumors. This study examined the neurocognitive outcomes of PBT in pediatric patients. A total of 8 patients, who received either PBT or photon radiotherapy (XRT), were evaluated with multiple cognitive functions, which include intelligence, memory, executive functions, and attention. Most of patients performed average-to-superior levels of neurocognitive functions (NCF), except that a deterioration of executive functions was revealed in two patients receiving XRT. This study might be the first one to show the maintenance of multidomain NCF after PBT.
质子束疗法（PBT）的开发是为了将放射治疗作为脑肿瘤治疗手段时的有害影响降至最低。本研究调查了儿科患者接受PBT后的神经认知结果。共有8名接受PBT或光子放射治疗（XRT）的患者接受了多种认知功能评估，这些功能包括智力、记忆、执行功能和注意力。除了两名接受XRT的患者出现执行功能衰退外，大多数患者的神经认知功能（NCF）表现为中等至优秀水平。本研究可能是首个表明PBT后多领域NCF得以维持的研究。
