小儿中枢神经系统放射肿瘤学：最新进展与新技术

Pediatric CNS Radiation Oncology: Recent Developments and Novel Techniques.

作者信息

Oh Justin, Patel Samir, Schlosser Mary-Pat, Arifin Andrew J, Oliveira Carol, Charpentier Anne-Marie, Tsang Derek S

机构信息

BC Cancer-Vancouver, Vancouver, BC V5Y 4E6, Canada.

Cross Cancer Institute, Edmonton, AB T6G 1Z2, Canada.

出版信息

Curr Oncol. 2025 Mar 20;32(3):180. doi: 10.3390/curroncol32030180.

DOI:10.3390/curroncol32030180

PMID:40136384

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11941344/

Abstract

Radiation therapy (RT) is a cornerstone in the management of pediatric central nervous system (CNS) tumors. Recent advancements in RT delivery and techniques aim to enhance therapeutic effectiveness while minimizing both acute and long-term complications associated with pediatric brain RT. This paper highlights innovative developments in the field, including the clinical indications, benefits, and challenges of proton therapy and stereotactic radiotherapy. The ongoing refinement of risk-adapted RT volumes is highlighted, with examples of newly proposed germinoma RT volumes and hippocampal-sparing RT. Additionally, emerging experimental approaches, including FLASH therapy and theranostics, are also discussed as promising future directions. Further prospective, multi-institutional collaborative studies are essential to validate and expand upon the benefits outlined in this review.

摘要

放射治疗（RT）是小儿中枢神经系统（CNS）肿瘤管理的基石。放射治疗的交付和技术方面的最新进展旨在提高治疗效果，同时将与小儿脑部放疗相关的急性和长期并发症降至最低。本文重点介绍了该领域的创新发展，包括质子治疗和立体定向放射治疗的临床适应症、益处和挑战。文中强调了风险适应性放疗体积的不断完善，并列举了新提出的生殖细胞瘤放疗体积和海马体保留放疗的例子。此外，还讨论了包括FLASH治疗和治疗诊断学在内的新兴实验方法，认为它们是有前景的未来发展方向。进一步的前瞻性、多机构合作研究对于验证和扩展本综述中概述的益处至关重要。