Department of Medical Biotechnology, Tabriz University of Medical Sciences, Tabriz, Iran; Stem Cell and Regenerative Medicine Institute (SCARM), Tabriz University of Medical Sciences, Tabriz, Iran.
Stem Cell and Regenerative Medicine Institute (SCARM), Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2018 Oct;106:163-174. doi: 10.1016/j.biopha.2018.06.109. Epub 2018 Jun 27.
Endometriosis refers to the growth of ectopic endometrial tissue outside the uterine cavity. About 10-15% of female in reproductive age suffer from endometriosis. Several etiologies - such as oxidative stress, inflammatory factors and cytokines, genetic etiology, and hormone role - have been reported for endometriosis. Indeed, oxidative stress leads to abnormalities by the production of ROS and RNS. The mechanism of endometriosis genesis is a complicated process that concerns the alterations in cellular immunity. Also, endometriosis is a hormonal response that illustrates stimulation in steroid hormone production. Genetic polymolymorphisms and epigenetic factors are also important in endometriosis initiation and progression. This review paper presents the role of oxidative stress, reactive oxygen species (ROS), and antioxidants and inflammatory, genetic, and epigenetic factors involved in the initiation and progression of the endometriosis.
子宫内膜异位症是指异位的子宫内膜组织生长在子宫腔外。大约有 10-15%的育龄期女性患有子宫内膜异位症。据报道，子宫内膜异位症的病因有多种，如氧化应激、炎症因子和细胞因子、遗传病因和激素作用。事实上，氧化应激通过产生 ROS 和 RNS 导致异常。子宫内膜异位症的发生机制是一个复杂的过程，涉及细胞免疫的改变。此外，子宫内膜异位症是一种激素反应，表明甾体激素的产生受到刺激。遗传多态性和表观遗传因素也在子宫内膜异位症的发生和发展中起重要作用。本文综述了氧化应激、活性氧（ROS）和抗氧化剂以及炎症、遗传和表观遗传因素在子宫内膜异位症的发生和发展中的作用。
