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腹腔镜联合中医对子宫内膜异位症相关性不孕氧化应激的影响：一项系统评价与荟萃分析

Impact of combining laparoscopy with traditional Chinese medicine on oxidative stress in endometriosis-related infertility: A systematic review and meta-analysis.

作者信息

Lin Shaoqiao, Zhou Shanshan

机构信息

Community Health Service Center, Wanqingsha Town, Nansha District, Guangzhou City, Guangdong Province, China.

Zhuhai Xiangzhou District People's Hospital, Zhuhai City, Guangdong Province, China.

出版信息

Medicine (Baltimore). 2025 Apr 11;104(15):e41692. doi: 10.1097/MD.0000000000041692.

DOI:10.1097/MD.0000000000041692
PMID:40228263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11999423/
Abstract

BACKGROUND

To evaluate the effect of laparoscopic procedures integrated with traditional Chinese medicine (TCM), specifically aimed at enhancing blood flow and alleviating blood stasis, on oxidative stress levels in individuals with endometriosis-induced infertility.

METHODS

We performed a systematic quantitative review to evaluate the effects of laparoscopic surgery combined with TCM on oxidative stress in endometriosis-related infertility by enhancing blood circulation and resolving stasis. A literature search of 9 major databases was performed. Meta-analysis was performed using Review Manager version 5.4 (R Foundation for Statistical Computing, Vienna, Austria) and Stata Release 16.0 (StataCorp LLC, College Station, TX). This systematic review was registered with the International Prospective Register of Systematic Reviews (i.e., "PROSPERO") (registration number: CRD42024526800).

RESULTS

Thirteen trials comprising 1084 participants were included. Laparoscopy combined with TCM for promoting blood circulation and removing blood stasis significantly reduced the levels of 8-isoprostane prostaglandin F2α (mean difference [MD] -29.57 [95% confidence interval (CI) -32.65 to -26.49]; P < .001), regulated on activation, normal T cell expressed and secreted (MD -231.83 [95% CI -341.33 to -122.32]; P < .001), reactive oxygen species (MD -0.92; [95% CI -1.12 to -0.73]; P < .001), monocyte chemoattractant protein-1 (MD -31.23 [95% CI -42.70 to -19.77]; P < .001), and increased glutathione peroxidase (MD 31.45 [95% CI 26.04 to 36.87]; P < .001), vitamin E (MD 4.86 [95% CI 3.77 to 5.94]; P < .001), superoxide dismutase (standardized MD 0.92 [95% CI 0.41 to 1.42]; P < .001).

CONCLUSION

Compared with laparoscopic surgery alone, the combination of TCM for promoting blood circulation and removing blood stasis demonstrated the potential to ameliorate oxidative stress in patients with endometriosis-induced infertility. However, further large-scale clinical trials are required to confirm these findings.

摘要

背景

评估结合中医的腹腔镜手术对子宫内膜异位症所致不孕症患者氧化应激水平的影响，尤其旨在增强血流和化瘀。

方法

我们进行了一项系统定量综述，以评估腹腔镜手术联合中医通过促进血液循环和化瘀对子宫内膜异位症相关不孕症氧化应激的影响。检索了9个主要数据库。使用Review Manager 5.4版（奥地利维也纳R统计计算基金会）和Stata 16.0版（美国德克萨斯州大学站StataCorp有限责任公司）进行荟萃分析。该系统综述已在国际前瞻性系统综述注册库（即“PROSPERO”）注册（注册号：CRD42024526800）。

结果

纳入了13项试验，共1084名参与者。腹腔镜联合中医活血化瘀显著降低了8-异前列腺素F2α水平（平均差[MD] -29.57 [95%置信区间(CI) -32.65至-26.49]；P <.001），调节活化正常T细胞表达和分泌因子水平（MD -231.83 [95% CI -341.33至-122.32]；P <.001），活性氧水平（MD -0.92；[95% CI -1.12至-0.73]；P <.001），单核细胞趋化蛋白-1水平（MD -31.23 [95% CI -42.70至-19.77]；P <.001），并提高了谷胱甘肽过氧化物酶水平（MD 31.45 [95% CI 26.04至36.87]；P <.001）、维生素E水平（MD 4.86 [95% CI 3.77至5.94]；P <.001）、超氧化物歧化酶水平（标准化MD 0.92 [95% CI 0.41至1.42]；P <.001）。

结论

与单纯腹腔镜手术相比，中医活血化瘀联合治疗显示出改善子宫内膜异位症所致不孕症患者氧化应激的潜力。然而，需要进一步的大规模临床试验来证实这些发现。

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Jpn J Radiol. 2024 Aug;42(8):801-819. doi: 10.1007/s11604-024-01569-5. Epub 2024 Apr 25.
2
Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility.氧化应激作为潜在的轻微和轻度子宫内膜异位症相关不孕的潜在原因。
Int J Mol Sci. 2023 Feb 14;24(4):3809. doi: 10.3390/ijms24043809.
3
Oxidative Stress in Assisted Reproductive Techniques, with a Focus on an Underestimated Risk Factor.
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4
Endometriosis: An Inflammatory Disease That Requires New Therapeutic Options.子宫内膜异位症：一种需要新治疗选择的炎症性疾病。
Int J Mol Sci. 2022 Jan 28;23(3):1518. doi: 10.3390/ijms23031518.
5
Antioxidant supplementations ameliorate PCOS complications: a review of RCTs and insights into the underlying mechanisms.抗氧化补充剂可改善 PCOS 并发症：RCT 综述及潜在机制探讨。
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6
Role of sperm apoptosis and oxidative stress in male infertility: A narrative review.精子凋亡和氧化应激在男性不育中的作用：一篇叙述性综述。
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7
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Nat Rev Drug Discov. 2021 Sep;20(9):689-709. doi: 10.1038/s41573-021-00233-1. Epub 2021 Jun 30.
8
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Pain Res Manag. 2021 May 26;2021:5529741. doi: 10.1155/2021/5529741. eCollection 2021.
9
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10
Novel therapeutic targets to improve IVF outcomes in endometriosis patients: a review and future prospects.改善子宫内膜异位症患者 IVF 结局的新治疗靶点：综述与展望。
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