Razek Ahmed Abdel Khalek Abdel, Abdalla Ahmed, Barakat Tarik, El-Taher Heba, Ali Khadiga
Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura, Egypt.
Gastroenterology and Hepatology Unit of Mansoura Children Hospital, Mansoura Faculty of Medicine, Mansoura, Egypt.
Clin Imaging. 2018 Sep-Oct;51:318-322. doi: 10.1016/j.clinimag.2018.06.011. Epub 2018 Jun 26.
To assess multi-parametric MR imaging with apparent diffusion coefficient (ADC) and fat fraction (FF) in detection and quantification of bone marrow involvement in pediatric patients with Gaucher disease.
This study was conducted upon 29 pediatric patients with Gaucher disease and 13 age and sex matched controls that underwent diffusion-weighted MR imaging and dual-echo gradient recalled echo imaging. The ADC and FF of the bone marrow were calculated.
There was significant difference in ADC (P = 0.001) and FF (P = 0.001) of bone marrow between patients and controls. The cutoff ADC and FF differentiate patients from controls were 0.47 × 10 mm/s and 0.36 with area under the curve of 0.947 and 0.885 and accuracy of 86.5% and 83.8% respectively. There was significant difference in ADC (P = 0.001) and FF (P = 0.001) between untreated (n = 17) and treated (n = 12) patients. The cutoff ADC and FF differentiate untreated from treated patients were 0.39 × 10 mm/s and 0.27 with area under curve of 0.886 and 0.851 and accuracy of 88% and 84% respectively.
Multi-parametric MR imaging using ADC and FF are quantitative imaging parameters that can be used for detection and quantification of vertebral bone marrow involvement in pediatric patients with Gaucher disease.
评估采用表观扩散系数（ADC）和脂肪分数（FF）的多参数磁共振成像在检测和量化戈谢病患儿骨髓受累情况中的应用。
本研究纳入了29例戈谢病患儿及13例年龄和性别匹配的对照者，所有受试者均接受了扩散加权磁共振成像和双回波梯度回波成像检查。计算骨髓的ADC值和FF值。
患者与对照者骨髓的ADC值（P = 0.001）和FF值（P = 0.001）存在显著差异。区分患者与对照者的ADC值和FF值截断点分别为0.47×10⁻³mm²/s和0.36，曲线下面积分别为0.947和0.885，准确率分别为86.5%和83.8%。未治疗患者（n = 17）与治疗患者（n = 12）之间的ADC值（P = 0.001）和FF值（P = 0.001）存在显著差异。区分未治疗患者与治疗患者的ADC值和FF值截断点分别为0.39×10⁻³mm²/s和0.27，曲线下面积分别为0.886和0.851，准确率分别为88%和84%。
采用ADC值和FF值的多参数磁共振成像是定量成像参数，可用于检测和量化戈谢病患儿的椎体骨髓受累情况。
