Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura, 13551, Egypt.
Neuroradiology. 2019 Nov;61(11):1291-1296. doi: 10.1007/s00234-019-02286-x. Epub 2019 Sep 6.
To study diagnostic accuracy of diffusion tensor imaging (DTI) in differentiating malignant from benign compressed vertebrae.
This study was done on 43 patients with compressed vertebrae on conventional magnetic resonance study that underwent DTI. The mean diffusivity (MD) and fractional anisotropy (FA) of malignant (n = 24) and benign (n = 19) compressed vertebrae were calculated by two readers.
There was a significantly lower (P = 0.001) MD of both readers between malignant (0.74 ± 0.2 and 0.78 ± 0.2 × 10 mm/s) and benign (1.67 + 0.3 and 1.63 ± 0.3 × 10 mm/s) compressed vertebrae. The FA of malignant compressed vertebrae of both readers (0.55 ± 0.2 and 0.52 ± 0.1) was significantly higher (P = 0.001) than that of benign (0.26 ± 0.1 and 0.28 ± 0.1) compressed vertebrae. There was excellent inter-reader agreement between both readers using MD (K = 0.91) and FA (K = 0.86). The thresholds of MD and FA used for differentiating malignant from benign compressed vertebrae of both readers were 1.15 and 1.16 × 10 mm/s and 0.37 and 0.34 with area under the curve (AUC) of 0.98, 0.96, 0.93, and 0.92 and diagnostic accuracy of 95.3%, 88.4%, 90.1%, and 86.0% respectively. Combined MD and FA revealed AUC of 0.99 and 0.97 and diagnostic accuracy of 95.3% and 93.0% by both readers respectively.
DTI is a non-invasive technique providing accurate imaging parameters that can be used for differentiating malignant from benign compressed vertebrae.
研究弥散张量成像（DTI）在区分恶性与良性受压椎体中的诊断准确性。
对 43 例常规磁共振研究显示受压椎体的患者进行了 DTI 检查。由两位读者计算恶性（n=24）和良性（n=19）受压椎体的平均弥散度（MD）和各向异性分数（FA）。
两位读者均发现恶性（0.74±0.2 和 0.78±0.2×10mm/s）和良性（1.67+0.3 和 1.63±0.3×10mm/s）受压椎体之间的 MD 显著降低（P=0.001）。两位读者的恶性受压椎体 FA（0.55±0.2 和 0.52±0.1）明显高于良性（0.26±0.1 和 0.28±0.1）受压椎体（P=0.001）。两位读者之间 MD（K=0.91）和 FA（K=0.86）的读者间一致性均很好。两位读者用于区分恶性和良性受压椎体的 MD 和 FA 阈值分别为 1.15 和 1.16×10mm/s，0.37 和 0.34，曲线下面积（AUC）分别为 0.98、0.96、0.93 和 0.92，诊断准确性分别为 95.3%、88.4%、90.1%和 86.0%。MD 和 FA 联合显示，两位读者的 AUC 分别为 0.99 和 0.97，诊断准确性分别为 95.3%和 93.0%。
DTI 是一种非侵入性技术，可提供准确的成像参数，可用于区分恶性与良性受压椎体。
