Fowler Joshua J, Braley Katie L, Farero Ryan D, Russell Eugene T, Phiel Christopher J, Kisley Michael A, Albeck David S
Departments of Psychology.
Neuroscience Program, University of Washington, Seattle, Washington, USA.
Neuroreport. 2018 Sep 26;29(14):1145-1150. doi: 10.1097/WNR.0000000000001085.
In the central nervous system the neuropeptide oxytocin mediates a range of behaviors related primarily to emotionality. One factor that influences oxytocinergic communication in the human brain and correlates with emotional behaviors is the single nucleotide polymorphism rs53576 on the oxytocin receptor gene (OXTR). For example, variations in this OXTR genotype are related to parental, altruistic, and other prosocial behaviors. Electroencephalographic waveforms of visually evoked response potentials recorded at the midline parietal electrode site display a prominent component putatively involved with attention allocation called the late positive potential. The magnitude of the late positive potential was found to be significantly higher in homozygous G allele individuals compared with A allele carriers when viewing negative emotionally charged images. Inversely, A allele carriers rated these negative images as more arousing, when measured by the Self-Assessment Manikin rating scale. These data suggest that OXTR functioning contributes to visual processing and subjective experience of negative stimuli.
在中枢神经系统中，神经肽催产素介导一系列主要与情绪相关的行为。影响人类大脑中催产素能通讯并与情绪行为相关的一个因素是催产素受体基因（OXTR）上的单核苷酸多态性rs53576。例如，这种OXTR基因型的变异与亲代、利他及其他亲社会行为有关。在顶叶中线电极部位记录的视觉诱发电位的脑电图波形显示出一个突出成分，即可能与注意力分配有关的晚期正电位。当观看带有负面情绪的图像时，发现纯合G等位基因个体的晚期正电位幅度明显高于A等位基因携带者。相反，通过自我评估人体模型评分量表测量，A等位基因携带者将这些负面图像评为更具刺激性。这些数据表明，OXTR的功能有助于对负面刺激的视觉处理和主观体验。
