Choi Damee, Minote Natsumi, Watanuki Shigeki
Faculty of Design, Kyushu University, Fukuoka, Japan.
Japan Society for the Promotion of Science, Tokyo, Japan.
J Physiol Anthropol. 2017 Jan 26;36(1):12. doi: 10.1186/s40101-016-0125-3.
Oxytocin receptor (OXTR) gene polymorphisms are related to individual differences in emotional processing of social cues. However, whether OXTR polymorphisms affect emotional processing of nonsocial cues remains unclear. The present study investigated the relationship between the OXTR rs53576 polymorphism and emotional processing of social cues and nonsocial cues.
Event-related potentials were recorded from 88 male participants while images of humans and images of objects were presented as social cues and nonsocial cues, respectively.
First, the results showed that GG carriers of OXTR rs53576 showed more negative N1 (50-200 ms) than AA carriers in response to images of both humans and objects. Second, GG carriers showed more negative N2 (200-320 ms) than AA carriers in response to images of humans but not in response to images of objects. Third, GG carriers showed more negative N2 in response to images of humans than images of objects, whereas AA carriers showed the opposite pattern. Fourth, we observed no difference in late positive potential (600-1000 ms) to images of humans or objects that depended on the OXTR rs53576 polymorphism.
These results suggest that the OXTR rs53576 polymorphism affects emotional processing of not only social cues but also nonsocial cues in the very early stage (reflected in N1); however, the data also suggest that the OXTR rs53576 polymorphism is related specifically to increased emotional processing of social cues in the middle stage (reflected in N2).
催产素受体（OXTR）基因多态性与社会线索情绪加工的个体差异有关。然而，OXTR多态性是否影响非社会线索的情绪加工仍不清楚。本研究调查了OXTR rs53576多态性与社会线索和非社会线索情绪加工之间的关系。
记录了88名男性参与者的事件相关电位，同时分别呈现人类图像和物体图像作为社会线索和非社会线索。
首先，结果显示，OXTR rs53576的GG携带者在对人类和物体图像的反应中，比AA携带者表现出更多的负性N1（50 - 200毫秒）。其次，GG携带者在对人类图像的反应中比AA携带者表现出更多的负性N2（200 - 320毫秒），但对物体图像的反应中没有。第三，GG携带者对人类图像的反应比物体图像表现出更多的负性N2，而AA携带者表现出相反的模式。第四，我们观察到，取决于OXTR rs53576多态性，对人类或物体图像的晚期正电位（600 - 1000毫秒）没有差异。
这些结果表明，OXTR rs53576多态性不仅影响社会线索的情绪加工，也影响非社会线索在非常早期阶段的情绪加工（反映在N1中）；然而，数据也表明，OXTR rs53576多态性在中期阶段（反映在N2中）与社会线索情绪加工增加具体相关。
