Fagundes Raquel Aparecida Bandeira, Soder Taís Fátima, Grokoski Kamila Castro, Benetti Fábia, Mendes Roberta Hack
Universidade Regional Integrada do Alto Uruguai e das Missões, Frederico Westphalen, RS, Brasil.
Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
J Bras Nefrol. 2018 Jul-Sep;40(3):278-286. doi: 10.1590/2175-8239-jbn-3931. Epub 2018 Jun 21.
Chronic kidney disease (CKD) is a syndrome caused by the progressive reduction of renal function. This study aimed to systematically examine the effects of supplementation with probiotics in the treatment of CKD. Searches were carried out on databases MEDLINE (PubMed), SciELO, Cochrane, and Clinical Trials. Two independent reviewers selected the studies from which data was extracted. The search included papers written in English and Portuguese published in the 2012-2016 period describing randomized clinical trials. Eight of the 82 eligible articles met the inclusion criteria. Sample size ranged from 18 to 101 individuals with CKD. The duration of the included studies varied from four to 24 weeks. Most of the included articles reported positive effects in renal function and decreased levels of urea, blood urea nitrogen, ammonia, plasma p-cresol, p-cresyl sulfate, and indoxyl sulfate.
慢性肾脏病（CKD）是一种由肾功能进行性减退引起的综合征。本研究旨在系统地探讨补充益生菌治疗CKD的效果。我们在MEDLINE（PubMed）、SciELO、Cochrane和临床试验等数据库中进行了检索。两名独立的评审员挑选出用于提取数据的研究。检索范围包括2012年至2016年期间发表的用英文和葡萄牙文撰写的描述随机临床试验的论文。82篇符合条件的文章中有8篇符合纳入标准。样本量为18至101例CKD患者。纳入研究的持续时间从4周到24周不等。大多数纳入文章报告了对肾功能的积极影响以及尿素、血尿素氮、氨、血浆对甲酚、对甲酚硫酸盐和硫酸吲哚酚水平的降低。
