Chweh A Y, Ulloque R A, Swinyard E A, Wolf H H
Neurochem Res. 1985 Jul;10(7):871-7. doi: 10.1007/BF00964624.
The effect of picrotoxinin on [3H]flunitrazepam binding to benzodiazepine receptors was investigated. In mouse forebrain membranes, picrotoxinin inhibited basal, GABA- and pentobarbital-stimulated [3H]flunitrazepam binding; this inhibitory activity was temperature- and chloride ion-dependent. Scatchard analysis of the data indicates that picrotoxinin decreases the number of binding sites without altering binding affinity. In cerebellar membranes, picrotoxinin did not alter [3H]flunitrazepam receptor binding.
研究了印防己毒素对[3H]氟硝西泮与苯二氮䓬受体结合的影响。在小鼠前脑细胞膜中，印防己毒素抑制基础的、γ-氨基丁酸（GABA）和戊巴比妥刺激的[3H]氟硝西泮结合；这种抑制活性依赖于温度和氯离子。对数据进行Scatchard分析表明，印防己毒素减少了结合位点的数量，而不改变结合亲和力。在小脑细胞膜中，印防己毒素未改变[3H]氟硝西泮受体结合。
