Chweh A Y, Swinyard E A, Wolf H H
J Neurochem. 1983 Sep;41(3):830-3. doi: 10.1111/j.1471-4159.1983.tb04815.x.
The effect of various concentrations of pentylenetetrazol (PTZ) on [3H]flunitrazepam binding to benzodiazepine receptors was investigated by Hofstee and Hill plot analyses. These analyses indicate the presence of two PTZ binding sites in forebrain, whereas a single PTZ binding site is present in cerebellum. The relative proportions of the two PTZ binding sites in forebrain are close to those of benzodiazepine Type II and Type I receptors, respectively. These results suggest that PTZ may actually discriminate between different types of benzodiazepine receptors.
通过霍夫斯泰因和希尔作图分析研究了不同浓度的戊四氮（PTZ）对[3H]氟硝西泮与苯二氮䓬受体结合的影响。这些分析表明，前脑中存在两个PTZ结合位点，而小脑中存在一个PTZ结合位点。前脑中两个PTZ结合位点的相对比例分别接近苯二氮䓬II型和I型受体的比例。这些结果表明，PTZ实际上可能能够区分不同类型的苯二氮䓬受体。
