肾实质质量与99锝-二巯基丁二酸（99Tcm-DMSA）摄取绝对定量之间的关系。在生长猪身上的一项实验研究。

The relationship between renal parenchymal mass and absolute quantitation of 99Tcm-DMSA uptake. An experimental study in the growing pig.

作者信息

Godley M L, Ransley P G, Gordon I, Risdon R A, Vivian G, Todd-Pokropek A

出版信息

Nucl Med Commun. 1985 Jul;6(7):377-88. doi: 10.1097/00006231-198507000-00003.

DOI:10.1097/00006231-198507000-00003

Abstract

Five Gottingen minipigs from the same litter aged 1 month entered the study and right nephrectomies were performed at staggered intervals between weeks 1 and 5. Absolute renal uptake of 99Tcm-DMSA, expressed as a percentage of the administered dose, was recorded in each animal weekly before right nephrectomy and at weekly intervals for 5 weeks post-nephrectomy. Before nephrectomy absolute renal uptake of 99Tcm-DMSA ranged between 16.8 and 21.5% (mean 18.6%) per kidney with no difference between right and left kidneys. After right nephrectomy, uptake in the left kidney approximately doubled within 1 week. No correlation was shown between renal parenchymal mass and absolute 99Tcm-DMSA uptake in paired or solitary normal kidneys undergoing growth or compensatory growth.

摘要

来自同一窝的5只1月龄哥廷根小型猪进入研究，在第1周和第5周之间以交错的时间间隔进行右肾切除术。在右肾切除术前每周记录每只动物99锝-二巯基丁二酸（99Tcm-DMSA）的绝对肾脏摄取量，以给药剂量的百分比表示，并在肾切除术后5周内每周记录一次。肾切除术前，每侧肾脏99Tcm-DMSA的绝对肾脏摄取量在16.8%至21.5%之间（平均18.6%），左右肾之间无差异。右肾切除术后，左肾摄取量在1周内约增加一倍。在经历生长或代偿性生长的成对或单个正常肾脏中，肾实质质量与99Tcm-DMSA绝对摄取量之间未显示相关性。