Baillet G, Gagnadoux M F, Mathonnat F, de Vernejoul P, Broyer M
Nephrologie. 1986;7(4):143-5.
To assess the accuracy of renal function quantification with Tc 99m-DMSA in children, we compared DMSA renal uptake and creatinine clearance in 16 cases of children with single kidney. The age of the patients ranged from two month to fourteen years. DMSA renal uptake was measured 7 hours after injection and was normalized in percent of the injected activity. A significant correlation was found between creatinine clearance and DMSA uptake (Pearson's r = 0.866, p less than 0.01). Normal creatinine clearance in children (80 to 120 ml/min-1 X 1.73 m-2) allowed determination of normal renal uptake (36 to 60%). This study indicates that in cases of asymmetrical renal impairment renal uptake reflects split renal creatinine clearance. Since the former is much easier to measure, DMSA should play an important role in the evaluation of differential renal function.
为评估锝99m-二巯基丁二酸（Tc 99m-DMSA）对儿童肾功能定量分析的准确性，我们比较了16例单肾儿童的DMSA肾摄取率和肌酐清除率。患者年龄从2个月至14岁不等。注射后7小时测量DMSA肾摄取率，并以注射活性的百分比进行标准化。肌酐清除率与DMSA摄取率之间存在显著相关性（Pearson相关系数r = 0.866，p < 0.01）。儿童正常肌酐清除率（80至120 ml/min-1×1.73 m-2）可确定正常肾摄取率（36%至60%）。本研究表明，在不对称性肾功能损害的情况下，肾摄取率反映了分侧肾肌酐清除率。由于前者测量起来容易得多，DMSA在评估分肾功能方面应发挥重要作用。
