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Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study.Xpert MTB/RIF Ultra 检测结核分枝杆菌和利福平耐药:一项前瞻性多中心诊断准确性研究。
Lancet Infect Dis. 2018 Jan;18(1):76-84. doi: 10.1016/S1473-3099(17)30691-6. Epub 2017 Nov 30.
2
Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study.Xpert MTB/RIF Ultra 检测在 HIV 感染成人结核性脑膜炎中的诊断准确性:一项前瞻性队列研究。
Lancet Infect Dis. 2018 Jan;18(1):68-75. doi: 10.1016/S1473-3099(17)30474-7. Epub 2017 Sep 14.
3
Mycobacterial Musculoskeletal Infections.分枝杆菌性肌肉骨骼感染
Infect Dis Clin North Am. 2017 Jun;31(2):369-382. doi: 10.1016/j.idc.2017.01.007. Epub 2017 Mar 11.
4
Improved diagnostic sensitivity for tuberculous meningitis with Xpert(®) MTB/RIF of centrifuged CSF.采用Xpert(®)MTB/RIF检测离心脑脊液提高结核性脑膜炎的诊断敏感性。
Int J Tuberc Lung Dis. 2015 Oct;19(10):1209-15. doi: 10.5588/ijtld.15.0253.
5
Laboratory Diagnosis of Extra-pulmonary Tuberculosis (EPTB) in Resource-constrained Setting: State of the Art, Challenges and the Need.资源受限环境下肺外结核病(EPTB)的实验室诊断:现状、挑战与需求
J Clin Diagn Res. 2015 Apr;9(4):EE01-6. doi: 10.7860/JCDR/2015/12422.5792. Epub 2015 Apr 1.
6
Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in children: a systematic review and meta-analysis.Xpert MTB/RIF assay 检测在儿童肺结核诊断中的应用:一项系统评价和荟萃分析。
Lancet Respir Med. 2015 Jun;3(6):451-61. doi: 10.1016/S2213-2600(15)00095-8. Epub 2015 Mar 24.
7
Diagnostic accuracy of the Xpert MTB/RIF assay for extrapulmonary and pulmonary tuberculosis when testing non-respiratory samples: a systematic review.检测非呼吸道样本时,Xpert MTB/RIF检测法对肺外和肺结核的诊断准确性:一项系统评价
BMC Infect Dis. 2014 Dec 31;14:709. doi: 10.1186/s12879-014-0709-7.
8
Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults.用于检测成人肺结核及利福平耐药性的Xpert® MTB/RIF检测法
Cochrane Database Syst Rev. 2014 Jan 21;2014(1):CD009593. doi: 10.1002/14651858.CD009593.pub3.
9
Bone and joint tuberculosis.骨与关节结核。
Eur Spine J. 2013 Jun;22 Suppl 4(Suppl 4):556-66. doi: 10.1007/s00586-012-2331-y. Epub 2012 Jun 19.
10
Tuberculous arthritis revisited as a forgotten cause of monoarticular arthritis.结核性关节炎作为单关节关节炎被遗忘的病因再度受到关注。
Ann Saudi Med. 2011 Jul-Aug;31(4):398-401. doi: 10.4103/0256-4947.83210.

结核性关节炎:Xpert MTB/RIF检测结果为阴性不能排除感染!

Tuberculous arthritis: negative Xpert MTB/RIF assay does not rule out infection!

作者信息

Davis Rebecca, Higgens Clare, Cosgrove Catherine, Shur Joshua, Arkell Paul

机构信息

Infectious Diseases, St George's University Hospital NHS Foundation Trust, London, UK.

Radiology, St Mark's Hospital, Harrow, London.

出版信息

BMJ Case Rep. 2018 Jun 29;2018:bcr-2018-224288. doi: 10.1136/bcr-2018-224288.

DOI:10.1136/bcr-2018-224288
PMID:29959172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6040497/
Abstract

We present a case of a 31-year-old man of Indian origin with no previous medical history who presented with an inflamed knee. Treatment for bacterial infection was unsuccessful, and needle aspiration of the left knee effusion/collection was smear and culture positive for tuberculosis (TB), despite Xpert MTB/RIF being falsely negative. The patient was commenced on quadruple therapy for TB and within 2 months had improved significantly with no clinical evidence of ongoing inflammation.

摘要

我们报告一例31岁的印度裔男性病例,该患者既往无病史,因膝关节发炎前来就诊。针对细菌感染的治疗未成功,尽管Xpert MTB/RIF检测结果为假阴性,但左膝关节积液/积脓的针吸涂片和培养结果显示结核(TB)呈阳性。该患者开始接受四联抗结核治疗,2个月内病情显著改善,无持续炎症的临床证据。