Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth.
作者信息
Yang Yi, Li Chia-Wei, Chan Li-Chuan, Wei Yongkun, Hsu Jung-Mao, Xia Weiya, Cha Jong-Ho, Hou Junwei, Hsu Jennifer L, Sun Linlin, Hung Mien-Chie
机构信息
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
出版信息
Cell Res. 2018 Aug;28(8):862-864. doi: 10.1038/s41422-018-0060-4. Epub 2018 Jun 29.
Abstract
摘要
相似文献
1
Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth.外泌体程序性死亡配体1具有主动防御功能，可抑制T细胞对乳腺癌细胞的杀伤并促进肿瘤生长。
Cell Res. 2018 Aug;28(8):862-864. doi: 10.1038/s41422-018-0060-4. Epub 2018 Jun 29.
2
Transforming growth factor beta orchestrates PD-L1 enrichment in tumor-derived exosomes and mediates CD8 T-cell dysfunction regulating early phosphorylation of TCR signalome in breast cancer.转化生长因子β调控肿瘤来源外泌体中 PD-L1 的富集，并调节乳腺癌中 TCR 信号转导早期磷酸化，从而介导 CD8 T 细胞功能障碍。
Carcinogenesis. 2021 Feb 11;42(1):38-47. doi: 10.1093/carcin/bgaa092.
3
A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.一种纳米单元策略逆转了外泌体 PD-L1 的免疫抑制作用，并与增强的铁死亡有关。
Nat Commun. 2021 Sep 30;12(1):5733. doi: 10.1038/s41467-021-25990-w.
4
Cancer derived exosomes induce macrophages immunosuppressive polarization to promote bladder cancer progression.肿瘤来源的外泌体诱导巨噬细胞免疫抑制极化，促进膀胱癌进展。
Cell Commun Signal. 2021 Sep 14;19(1):93. doi: 10.1186/s12964-021-00768-1.
5
Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression.旁分泌信号通过上调 PD-L1 表达抑制抗肿瘤免疫。
Cancer Res. 2018 Jul 15;78(14):3761-3768. doi: 10.1158/0008-5472.CAN-18-0040. Epub 2018 May 22.
6
LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer.LSD1 缺失降低胃癌细胞外泌体 PD-L1 并恢复 T 细胞反应。
Mol Cancer. 2022 Mar 16;21(1):75. doi: 10.1186/s12943-022-01557-1.
7
PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression.PARP抑制剂上调PD-L1表达并增强癌症相关免疫抑制。
Clin Cancer Res. 2017 Jul 15;23(14):3711-3720. doi: 10.1158/1078-0432.CCR-16-3215. Epub 2017 Feb 6.
8
Clinical Significance of PD-L1 Exosomes in Plasma of Head and Neck Cancer Patients.头颈部癌症患者血浆中 PD-L1 外泌体的临床意义。
Clin Cancer Res. 2018 Feb 15;24(4):896-905. doi: 10.1158/1078-0432.CCR-17-2664. Epub 2017 Dec 12.
9
PD-1/PD-L1 Pathway in Breast Cancer.PD-1/PD-L1 通路在乳腺癌中的作用。
Oncol Res Treat. 2017;40(5):294-297. doi: 10.1159/000464353. Epub 2017 Mar 27.
10
BIN1 reverses PD-L1-mediated immune escape by inactivating the c-MYC and EGFR/MAPK signaling pathways in non-small cell lung cancer.BIN1 通过失活 c-MYC 和 EGFR/MAPK 信号通路逆转非小细胞肺癌中的 PD-L1 介导的免疫逃逸。
Oncogene. 2017 Nov 9;36(45):6235-6243. doi: 10.1038/onc.2017.217. Epub 2017 Jul 17.
引用本文的文献
1
Extracellular vesicles: biogenesis mechanism and impacts on tumor immune microenvironment.细胞外囊泡：生物发生机制及其对肿瘤免疫微环境的影响
J Biomed Sci. 2025 Sep 4;32(1):85. doi: 10.1186/s12929-025-01182-2.
2
Harnessing the potential of small extracellular vesicle biomarkers for cancer diagnosis and prognosis with advanced analytical technologies.利用先进分析技术挖掘细胞外小囊泡生物标志物在癌症诊断和预后方面的潜力。
J Transl Int Med. 2025 Jun 20;13(3):187-200. doi: 10.1515/jtim-2025-0019. eCollection 2025 Jun.
3
Strategies to Overcome PD-1/PD-L1 Blockade Resistance: Focusing on Combination with Immune Checkpoint Blockades.克服PD-1/PD-L1阻断耐药的策略：聚焦于与免疫检查点阻断剂联合使用
J Cancer. 2025 Jul 24;16(11):3425-3449. doi: 10.7150/jca.108163. eCollection 2025.
4
CD47 antibody-armed oncolytic adenovirus promotes chimeric antigen receptor macrophage phagocytosis and antitumor immunity.CD47抗体武装的溶瘤腺病毒促进嵌合抗原受体巨噬细胞吞噬作用和抗肿瘤免疫。
Exp Hematol Oncol. 2025 Aug 14;14(1):106. doi: 10.1186/s40164-025-00696-7.
5
Mechanical regulation of extracellular vesicle activity during tumour progression.肿瘤进展过程中细胞外囊泡活性的机械调节
Nat Biomed Eng. 2025 Aug 6. doi: 10.1038/s41551-025-01446-0.
6
Targeting Exosomal PD-L1 as a New Frontier in Cancer Immunotherapy.靶向外泌体程序性死亡受体配体1作为癌症免疫治疗的新前沿
Curr Issues Mol Biol. 2025 Jul 8;47(7):525. doi: 10.3390/cimb47070525.
7
"Small extracellular vesicles: messengers at the service of breast cancer agenda in the primary and distant microenvironments".小细胞外囊泡：在原发性和远处微环境中服务于乳腺癌进程的信使
J Exp Clin Cancer Res. 2025 Jul 21;44(1):216. doi: 10.1186/s13046-025-03471-y.
8
Exosomal PD-L1 detection in cancer predictive biomarker for response to immune checkpoint blockade therapy.癌症中检测外泌体程序性死亡受体配体1作为免疫检查点阻断疗法反应的预测生物标志物。
Front Immunol. 2025 Jul 3;16:1603855. doi: 10.3389/fimmu.2025.1603855. eCollection 2025.
9
The role of exosomes in immunopathology and potential therapeutic implications.外泌体在免疫病理学中的作用及潜在治疗意义。
Cell Mol Immunol. 2025 Jul 14. doi: 10.1038/s41423-025-01323-5.
10
Synergizing sono-piezo with exosome suppression using doping-engineered hydroxyapatite for potentiated tumor treatment through immunoactivation.利用掺杂工程化羟基磷灰石将超声压电与外泌体抑制协同作用，通过免疫激活增强肿瘤治疗效果。
J Nanobiotechnology. 2025 Jul 8;23(1):495. doi: 10.1186/s12951-025-03564-y.
本文引用的文献
1
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression.宿主表达 PD-L1 决定 PD-L1 通路阻断介导的肿瘤消退疗效。
J Clin Invest. 2018 Feb 1;128(2):805-815. doi: 10.1172/JCI96113. Epub 2018 Jan 16.
2
Clinical Significance of PD-L1 Exosomes in Plasma of Head and Neck Cancer Patients.头颈部癌症患者血浆中 PD-L1 外泌体的临床意义。
Clin Cancer Res. 2018 Feb 15;24(4):896-905. doi: 10.1158/1078-0432.CCR-17-2664. Epub 2017 Dec 12.
3
Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis.外泌体递送的 EGFR 调节肝微环境促进胃癌肝转移。
Nat Commun. 2017 Apr 10;8:15016. doi: 10.1038/ncomms15016.
4
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice.肿瘤和宿主细胞 PD-L1 是介导抑制小鼠抗肿瘤免疫所必需的。
Nat Commun. 2017 Feb 21;8:14572. doi: 10.1038/ncomms14572.
5
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations.用于癌症治疗的PD-L1（B7-H1）和PD-1通路阻断：作用机制、反应生物标志物及联合应用
Sci Transl Med. 2016 Mar 2;8(328):328rv4. doi: 10.1126/scitranslmed.aad7118.
6
Exosome mediated communication within the tumor microenvironment.肿瘤微环境中的细胞外囊泡介导的通讯。
J Control Release. 2015 Dec 10;219:278-294. doi: 10.1016/j.jconrel.2015.06.029. Epub 2015 Jul 2.
7
Microenvironmental regulation of tumor progression and metastasis.肿瘤演进和转移的微环境调控。
Nat Med. 2013 Nov;19(11):1423-37. doi: 10.1038/nm.3394.
8
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity.外泌体介导 IFN-α 诱导的抗病毒活性的细胞间传递。
Nat Immunol. 2013 Aug;14(8):793-803. doi: 10.1038/ni.2647. Epub 2013 Jul 7.
9
Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression.Rab27a 支持外泌体依赖和非依赖的机制，这些机制可以修饰肿瘤微环境，并促进肿瘤进展。
Cancer Res. 2012 Oct 1;72(19):4920-30. doi: 10.1158/0008-5472.CAN-12-0925. Epub 2012 Aug 3.
10
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.黑色素瘤外泌体通过 MET 使骨髓祖细胞向促转移表型发展。
Nat Med. 2012 Jun;18(6):883-91. doi: 10.1038/nm.2753.
Zotero 插件