Kotlińska J, Langwiński R
Pol J Pharmacol Pharm. 1985 Mar-Apr;37(2):103-11.
The action of opiate receptor agonists: (D-Ala2)-methionine enkephalinamide (D-MEA), morphine, heroin, etorphine, and antagonists: naloxone and diprenorphine on audiogenic seizures was tested during ethanol abstinence. The action of diazepam and clonidine was also tested Morphine (5 and 20 mg/kg), but not heroin and etorphine, given intraperitoneally inhibited the seizures, similarly as intraventricularly administered D-MEA did. However, morphine given by this route was ineffective. Diazepam and clonidine inhibited audiogenic seizures: the action of clonidine was counteracted by yohimbine, but not by prazosin. The results may be considered as supporting the hypothesis on the participation of opioid system in ethanol abstinence. However, the participation of gabergic and noradrenergic systems cannot be ruled out: these systems may possibly interact with the opioid system in evoking the symptoms of ethanol abstinence.
在乙醇戒断期间，测试了阿片受体激动剂：（D-丙氨酸²）-甲硫氨酸脑啡肽酰胺（D-MEA）、吗啡、海洛因、埃托啡，以及拮抗剂：纳洛酮和二丙诺啡对听源性惊厥的作用。还测试了地西泮和可乐定的作用。腹腔注射吗啡（5和20mg/kg），但不是海洛因和埃托啡，可抑制惊厥，脑室内注射D-MEA也有同样效果。然而，通过这种途径给予吗啡无效。地西泮和可乐定抑制听源性惊厥：可乐定的作用可被育亨宾抵消，但不能被哌唑嗪抵消。这些结果可被视为支持阿片系统参与乙醇戒断的假说。然而，不能排除γ-氨基丁酸能系统和去甲肾上腺素能系统的参与：这些系统可能在引发乙醇戒断症状时与阿片系统相互作用。
