乙醇戒断期间的听源性惊厥可被δ阿片受体激动剂阻断。
Audiogenic seizures during ethanol withdrawal can be blocked by a delta opioid agonist.
作者信息
Kotlińska J, Langwiński R
出版信息
Drug Alcohol Depend. 1986 Dec;18(4):361-7. doi: 10.1016/0376-8716(86)90100-6.
PMID:3028746
Abstract
In rats the influence of the delta opioid agonists [Leu]enkephalin, [D-Ala2-D-Leu5]enkephalin, [D-Ala2]methionine enkephalinamide and synthetic analogue of [Met]enkephalin: Tyr-D-Ala-Gly-Phe-D-Leu-OMe on audiogenic seizures was tested during ethanol abstinence. All investigated drugs significantly inhibited this ethanol withdrawal symptom. The results are compatible with the hypothesis of opioid involvement in the ethanol abstinence syndrome.
摘要
在大鼠中，研究了δ阿片样物质激动剂[亮氨酸]脑啡肽、[D-丙氨酸2-D-亮氨酸5]脑啡肽、[D-丙氨酸2]甲硫氨酸脑啡肽酰胺以及[甲硫氨酸]脑啡肽的合成类似物：酪氨酰-D-丙氨酸-甘氨酸-苯丙氨酸-D-亮氨酸-甲酯对乙醇戒断期间听源性惊厥的影响。所有研究药物均显著抑制了这种乙醇戒断症状。这些结果与阿片样物质参与乙醇戒断综合征的假说相符。
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