Iwersen-Bergmann S, Lehmann S, Heinemann A, Schröder C, Müller A, Jungen H, Andresen-Streichert H, Pueschel K, Vidal C, Mercer-Chalmers-Bender K
Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Institute of Legal Medicine, University Hospital of Cologne, Cologne, Germany.
Int J Legal Med. 2019 Jan;133(1):123-129. doi: 10.1007/s00414-018-1882-9. Epub 2018 Jun 29.
Reports of intoxications with new psychoactive substances (NPS) mostly involve young people, as they are the main consumers of these types of drugs. This report centers on a case that was unusual due to it being a mass-poisoning event involving middle-aged individuals who had consumed a combination of the two different new psychoactive drugs 2,5-dimethoxy-4-ethylphenethylamine (2C-E) and 1-(8-bromofuro[2,3-f][1]benzofuran-4-yl)-2-propanamine (Bromo-DragonFly, BDF).
The mass poisoning of 29 individuals (24-56 years old) resulted in their admission to six different hospitals with severe symptoms of intoxication. All symptoms manifested after consumption of an unknown drug formulation around lunchtime during an esoteric weekend seminar.
Urine (n = 11) and blood samples (n = 29), collected from the 29 individuals for police investigation, were analyzed with immunochemical techniques, GC/MS and LC-MS/MS. 2C-E was confirmed in seven urine samples, but not in blood. BDF was confirmed in all urine samples, and in 17 blood samples. The blood samples exhibited BDF concentrations between ca. 0.6 and ca. 2.0 μg/L, while urine concentrations of BDF ranged from ca. 1.6 to 35 μg/L. The concentration of 2C-E in urine was found to be between ca. 1.5 and 183 μg/L. All patients made a complete recovery, although some had required mechanical ventilation.
The investigation and the presentation of this case illustrates not only mass intoxication with 2C-E and BDF, with corresponding blood and urine concentrations, but also the necessity of collecting urine samples in cases where NPS-consumption is suspected, in order to improve the chances of analytical detection.
新型精神活性物质（NPS）中毒报告大多涉及年轻人，因为他们是这类毒品的主要消费者。本报告聚焦于一起不同寻常的案例，这是一起群体中毒事件，涉及中年个体，他们摄入了两种不同的新型精神活性药物2,5-二甲氧基-4-乙基苯乙胺（2C-E）和1-(8-溴呋喃并[2,3-f][1]苯并呋喃-4-基)-2-丙胺（溴代蜻蜓，BDF）的混合物。
29名年龄在24至56岁之间的个体群体中毒，因严重中毒症状被送往六家不同医院。所有症状均在一个神秘的周末研讨会上午餐时间左右食用一种未知药物制剂后出现。
从这29名个体采集尿液（n = 11）和血液样本（n = 29）用于警方调查，采用免疫化学技术、气相色谱/质谱联用（GC/MS）和液相色谱-串联质谱联用（LC-MS/MS）进行分析。在7份尿液样本中确认存在2C-E，但血液中未检出。所有尿液样本以及17份血液样本中均确认存在BDF。血液样本中BDF浓度约在0.6至2.0μg/L之间，而尿液中BDF浓度范围约为1.6至35μg/L。尿液中2C-E浓度在约1.5至183μg/L之间。所有患者均完全康复，尽管有些患者需要机械通气。
该病例的调查和呈现不仅说明了2C-E和BDF群体中毒情况以及相应的血液和尿液浓度，还表明在怀疑有新型精神活性物质消费的情况下采集尿液样本的必要性，以便提高分析检测的几率。
