Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, PR China; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, Shaanxi 710061, PR China.
Department of Ophthalmology, The First Affiliated Hospital, Xi'an Medical University, Xi'an, Shaanxi 710077, PR China.
Clin Chim Acta. 2018 Oct;485:210-217. doi: 10.1016/j.cca.2018.06.028. Epub 2018 Jun 28.
Tumor necrosis factor-alpha (TNF-α) is produced by multinuclear giant cells and acts as local intensification signals in pathological processes associated with chronic eye inflammation. This meta-analysis was performed to provide a better understanding of the relationship between TNF-α and diabetic retinopathy (DR).
Online electric databases were searched to retrieve all relevant articles published before October 2017. The standard mean difference (SMD) and their 95% confidence intervals (CI) were included and then pooled with a random effects model.
A total of 16 articles with 1286 participants were included in this meta-analysis. No difference in the level of TNF-α was found between DR patients and healthy controls (SMD = 0.39, 95% CI = -0.09 to 0.68, P = 0.01). Subgroup analysis showed that with respect to the level of TNF-α, the association was significant for studies conducted in Europe (SMD: 0.57, 95% CI: 0.11-1.02, P = 0.01), patients with type 1 DM (SMD: 1.06, 95% CI: 0.09-2.04, P = 0.03), studies based on serum samples (SMD: 0.57, 95% CI: 0.12-1.02, P = 0.01) and studies with a sample size >50 (SMD: 0.39, 95% CI: 0.03-0.75, P = 0.04).
The results this meta-analysis indicated that the level of TNF-α in DR patients was significantly different from that in the healthy controls, so TNF-α represents a candidate biomarker for DR.
肿瘤坏死因子-α（TNF-α）由多核巨细胞产生，在与慢性眼部炎症相关的病理过程中充当局部强化信号。本荟萃分析旨在更好地了解 TNF-α与糖尿病视网膜病变（DR）之间的关系。
在线电子数据库中检索了截至 2017 年 10 月之前发表的所有相关文章。纳入了标准均数差（SMD）及其 95%置信区间（CI），然后采用随机效应模型进行汇总。
本荟萃分析共纳入 16 项研究，共 1286 名参与者。DR 患者与健康对照组的 TNF-α 水平无差异（SMD=0.39，95%CI=-0.09 至 0.68，P=0.01）。亚组分析显示，就 TNF-α 水平而言，欧洲研究（SMD：0.57，95%CI：0.11-1.02，P=0.01）、1 型 DM 患者（SMD：1.06，95%CI：0.09-2.04，P=0.03）、基于血清样本的研究（SMD：0.57，95%CI：0.12-1.02，P=0.01）和样本量>50 的研究（SMD：0.39，95%CI：0.03-0.75，P=0.04）的关联具有统计学意义。
本荟萃分析的结果表明，DR 患者的 TNF-α 水平与健康对照组有显著差异，因此 TNF-α 可能是 DR 的候选生物标志物。
