Lee Jong-Han, Lee Woonhyung, Kwon Oh Hun, Kim Jeong-Ho, Kwon Oh Woong, Kim Kyung Hwan, Lim Jong-Baeck
Department of Laboratory Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul, Korea 120-752.
Ann Clin Lab Sci. 2008 Autumn;38(4):361-7.
To evaluate the usefulness of cytokine levels of peripheral blood in diabetic retinopathy (DR), demographic and biochemical parameters including low-density lipoprotein (LDL) diameter as well as cytokine profiles were analyzed in 74 patients with type 2 diabetes mellitus (DM), with DR (n=46) or without DR (n=28). DM duration was longer in the patients with DR than without (p<0.001). Serum glucose (p=0.005) and total cholesterol (p=0.029) levels were higher in DM patients with DR than DM patients without DR. Plasma LDL diameter, interleukin-6 (IL-6), and interleukin-8 (IL-8) showed significant differences among the different degrees of DR severity in analysis of variance (ANOVA) with no definite trend. The risk of DR in DM patients was decreased by an increase of interleukin-10 (IL-10) level [odds ratio (OR)=0.152; confidence interval (CI): 0.028-0.817]. Plasma LDL diameter was smaller and IL-6 and tumor necrosis factor-alpha (TNF-alpha) levels were higher in DM patients with proliferative diabetic retinopathy (PDR) compared to those with non-proliferative diabetic retinopathy (NPDR) (p<0.05). We found that higher IL-10 levels were related to lower risk of DR in DM patients. Levels of IL-6 and TNF-alpha as well as LDL diameter may be helpful in the prediction of PDR in DM patients with DR.
为评估外周血细胞因子水平在糖尿病视网膜病变（DR）中的作用，我们分析了74例2型糖尿病（DM）患者的人口统计学和生化参数，包括低密度脂蛋白（LDL）直径以及细胞因子谱，这些患者中有DR（n = 46）或无DR（n = 28）。DR患者的DM病程比无DR患者更长（p < 0.001）。有DR的DM患者的血清葡萄糖（p = 0.005）和总胆固醇（p = 0.029）水平高于无DR的DM患者。在方差分析（ANOVA）中，血浆LDL直径、白细胞介素-6（IL-6）和白细胞介素-8（IL-8）在不同程度的DR严重程度之间显示出显著差异，但无明确趋势。DM患者中DR的风险随着白细胞介素-10（IL-10）水平的升高而降低[比值比（OR）= 0.152；置信区间（CI）：0.028 - 0.817]。与非增殖性糖尿病视网膜病变（NPDR）患者相比，增殖性糖尿病视网膜病变（PDR）的DM患者血浆LDL直径更小，IL-6和肿瘤坏死因子-α（TNF-α）水平更高（p < 0.05）。我们发现较高的IL-10水平与DM患者较低的DR风险相关。IL-6和TNF-α水平以及LDL直径可能有助于预测患有DR的DM患者的PDR。
