School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia; Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Callaghan, NSW, Australia; Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia; Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Callaghan, NSW, Australia; Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Neurosci Biobehav Rev. 2018 Oct;93:26-37. doi: 10.1016/j.neubiorev.2018.06.023. Epub 2018 Jun 28.
Chronic stress has been extensively linked to disturbances in glutamatergic signalling. Emerging from this field of research is a considerable number of studies identifying the ability of purines at the pre-, post-, and peri-synaptic levels to tune glutamatergic neurotransmission. While the evidence describing purinergic control of glutamate has continued to grow, there has been relatively little attention given to how chronic stress modulates purinergic functions. The available research on this topic has demonstrated that chronic stress can not only disturb purinergic receptors involved in the regulation of glutamate neurotransmission, but also perturb glial-dependent purinergic signalling. This review will provide a detailed examining of the complex literature relating to glutamatergic-purinergic interactions with a focus on both neuronal and glial contributions. Once these detailed interactions have been described and contextualised, we will integrate recent findings from the field of stress research.
慢性应激与谷氨酸能信号传递紊乱密切相关。这一研究领域涌现出大量研究，指出嘌呤类物质在突触前、突触后和突触间隙水平调节谷氨酸能神经传递的能力。虽然描述嘌呤能控制谷氨酸的证据不断增加，但对于慢性应激如何调节嘌呤能功能的关注相对较少。这一主题的现有研究表明，慢性应激不仅会干扰参与调节谷氨酸神经传递的嘌呤能受体，还会扰乱依赖神经胶质的嘌呤能信号。本综述将详细研究与谷氨酸-嘌呤能相互作用相关的复杂文献，重点关注神经元和神经胶质的贡献。一旦描述和语境化了这些详细的相互作用，我们将整合应激研究领域的最新发现。
