吗啡和纳洛酮对大鼠血浆、脑和垂体中促肾上腺皮质激素（ACTH）及β-内啡肽水平的影响。

Effect of morphine and naloxone on the levels of ACTH and beta-endorphin in plasma, brain and pituitary of rats.

作者信息

Bruni G, Dal Pra P, Fiaschi A I, Segre G

出版信息

Pharmacol Res Commun. 1985 Jul;17(7):659-69. doi: 10.1016/0031-6989(85)90073-6.

Abstract

The effect of i.p. administration of morphine (25 mg/kg) and of naloxone (50 mg/kg) on the levels of ACTH and beta-endorphin in plasma, in brain and in pituitary has been studied in rats. An opposite effect morphine and naloxone is seen in plasma ACTH with an increase elicited by morphine and a decrease produced by naloxone. Small changes are seen in plasma levels of beta-endorphin as well as in ACTH and in beta-endorphin levels in brain and in pituitary. To every change in ACTH levels in plasma an opposite change in ACTH brain levels is observed.

摘要

已经在大鼠中研究了腹腔注射吗啡（25毫克/千克）和纳洛酮（50毫克/千克）对血浆、脑和垂体中促肾上腺皮质激素（ACTH）和β-内啡肽水平的影响。吗啡和纳洛酮对血浆ACTH有相反的作用，吗啡引起其升高，纳洛酮使其降低。血浆β-内啡肽水平以及脑和垂体中的ACTH和β-内啡肽水平有微小变化。血浆中ACTH水平的每一个变化都伴随着脑ACTH水平的相反变化。